Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in cd-1 mouse pups 英文参考文献.docVIP

Environmental Health BioMedCentral Research Open Access Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in cd-1 mouse pups Aldina Venerosi*?, Laura Ricceri?, Maria Luisa Scattoni and Gemma Calamandrei Address: Section of Neurotoxicology and Neuroendocrinology Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Roma, Italy Email: Aldina Venerosi* - aldina.venerosi@iss.it; Laura Ricceri - laura.ricceri@iss.it; Maria Luisa Scattoni - marialuisa.scattoni@iss.it; Gemma Calamandrei - gemma.calamandrei@iss.it * Corresponding author ?Equal contributors Published: 30 March 2009 Received: 4 December 2008 Accepted: 30 March 2009 Environmental Health 2009, 8:12 doi:10.1186/1476-069X-8-12 This article is available from: /content/8/1/12 ? 2009 Venerosi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Chlorpyrifos (CPF) is a non-persistent organophosphate (OP) largely used as pesticide. Studies from animal models indicate that CPF is a developmental neurotoxicant able to target immature central nervous system at dose levels well below the threshold of systemic toxicity. So far, few data are available on the potential short- and long-term adverse effects in children deriving from low-level exposures during prenatal life and infancy. Methods: Late gestational exposure [gestational day (GD) 14–17] to CPF at the dose of 6 mg/kg was evaluated in CD-1 mice during early development, by assessment of somatic and sensorimotor maturation [reflex-battery on postnatal days (PNDs) 3, 6, 9, 12 and 15] and ultrasound emission after isolation from the mother and siblings (PNDs 4, 7 and 10). Pups mo