Prepregnancy obesity and the risk of gestational diabetes mellitus 英文参考文献.docVIP

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Prepregnancy obesity and the risk of gestational diabetes mellitus 英文参考文献.doc

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Prepregnancy obesity and the risk of gestational diabetes mellitus 英文参考文献

KongubolandPhupongBMCPregnancyandChildbirth2011,11:59 /1471-2393/11/59 RESEARCH ARTICLE OpenAccess Prepregnancyobesityandtheriskofgestational diabetesmellitus AnussaraKongubol?andVorapongPhupong*? Abstract Background:Prepregnancyobesityisassociatedwithincreasedriskforadversepregnancyoutcomesuchas gestationaldiabetesmellitus(GDM),gestationalhypertension,preeclampsia,fetalmacrosomiaandtheneedfor cesareandelivery.TheobjectivesofthisstudyassessedwhetherThaiwomenclassifiedasobeseaccordingto WHO’srecommendedbodymassindex(BMI)forAsianswereatriskfordevelopinggestationaldiabetesmellitus (GDM)andothercomplicationssuchaspreeclampsia,gestationalhypertensionandfetalmacrosomia. Methods:Twohundredandfortywomenparticipatedinthisstudyandfollowedprospectivelyuntildelivery.Half ofthewomen(n=120)wereobese(BMI≥27.5kg/m2)andtheotherhalf(n=120)hadnormalweight(BMI 18.5-23kg/m2).Maternaldemographicdata,obstetricandneonataloutcomesfrombothgroupswerecomparedto eachother.Relativeriskand95%confidenceinterval(CI)werecalculated. Results:Comparedtonormalweightwomen,obeseThaiwomenwerenotatincreasedriskforgestational diabetesmellitus(RR=0.9[95%CI0.6-1.4]).Relativeriskofpreeclampsiaandfetalmacrosomiainobesewomen were0.7[95%CI0.2-3.3]and1.4[95%CI0.5-4.3],respectively.Relativeriskofgestationalhypertensioninobese womenwas12[95%CI1.6-90.8]. Conclusion:WhenWHO’sclassificationofobesitywasusedforAsianpopulations,prepregnancyobesitywithout metabolicproblemsdidnotincreasetheriskforGDM,preeclampsiaandfetalmacrosomiainThaiwomen.But, prepregnancyobesitycontinuedtoincreasetheriskfordevelopinggestationalhypertension. Keywords:prepregnancy,obesity,gestationaldiabetesmellitus,preeclampsia,macrosomia Background is associated with increased risk for adverse pregnancy Obesityisamajorpublichealthconcernanditsimpact outcome such as gestational diabetes mellitus (GDM), onpregnancycontinuestogrowintheworldaswellas gestationalhypertension,preeclampsia,fetalmacrosomia inThailand. Theprevalence of obesity in T