Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population 英文参考文献.docVIP

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Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population 英文参考文献.doc

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Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population 英文参考文献

Cough BioMedCentral Short report Open Access Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population Hisako Matsumoto*, Akio Niimi, Masaya Takemura, Tetsuya Ueda, Masafumi Yamaguchi, Hirofumi Matsuoka, Makiko Jinnai, Kazuo Chin and Michiaki Mishima Address: Department of Respiratory Medicine, Kyoto University, Kyoto, Japan Email: Hisako Matsumoto* - hmatsumo@kuhp.kyoto-u.ac.jp; Akio Niimi - niimi@kuhp.kyoto-u.ac.jp; Masaya Takemura - m- takemura@kitano-hp.or.jp; Tetsuya Ueda - uedate@kuhp.kyoto-u.ac.jp; Masafumi Yamaguchi - myama@kuhp.kyoto-u.ac.jp; Hirofumi Matsuoka - hiromtok@kuhp.kyoto-u.ac.jp; Makiko Jinnai - majin43@kuhp.kyoto-u.ac.jp; Kazuo Chin - chink@kuhp.kyoto-u.ac.jp; Michiaki Mishima - mishima@kuhp.kyoto-u.ac.jp * Corresponding author Published: 08 January 2007 Received: 16 May 2006 Accepted: 08 January 2007 Cough 2007, 3:1 doi:10.1186/1745-9974-3 -1 This article is available from: /content/3 /1/1 ? 2007 Matsumoto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Gastro-oesophageal reflux (GOR) is one of the most common causes of chronic cough in Western countries, responsible for 10 to 40% of cases. In Japan, however, GOR-associated chronic cough (GOR-CC) has been rarely reported and its clinical manifestation including frequency of concomitant reflux laryngitis is poorly known. We have analyzed prevalence and clinical characteristics of patients who were diagnosed as having GOR-CC among adult patients with chronic cough (≥ 8 weeks) who visited our asthma and cough clinic over a period of 19 months. Diagnosis of GOR-CC was based on the response of coughing to a proton-pump inhibitor (lansoprazole?) and/o