Prevalence of reverse transcriptase and protease mutations associated with antiretroviral drug resistance among drug-na?ve HIV-1 infected pregnant women in Kagera and Kilimanjaro regions, Tanzania 英文参考文献.docVIP
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Prevalence of reverse transcriptase and protease mutations associated with antiretroviral drug resistance among drug-na?ve HIV-1 infected pregnant women in Kagera and Kilimanjaro regions, Tanzania 英文参考文献
AIDS Research and Therapy
BioMedCentral
Research
Open Access
Prevalence of reverse transcriptase and protease mutations
associated with antiretroviral drug resistance among drug-na?ve
HIV-1 infected pregnant women in Kagera and Kilimanjaro regions,
Tanzania
Balthazar M Nyombi*1,2,3, Carol Holm-Hansen2,4, Knut I Kristiansen3,
Gunnar Bjune2 and Fredrik Müller3
Address: 1Research Laboratory, Kilimanjaro Christian Medical College, Moshi, Tanzania, 2International Community Health, Institute of General
Practice and Community Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, 3Institute of Microbiology, Faculty of Medicine,
University of Oslo and Rikshospitalet University Hospital, Oslo, Norway and 4Division of Infectious Disease Control, Norwegian Institute of
Public Health, Oslo, Norway
Email: Balthazar M Nyombi* - bnyombi@; Carol Holm-Hansen - carol.holm-hansen@fhi.no;
Knut I Kristiansen - knut.ivan.kristiansen@rr-research.no; Gunnar Bjune - g.a.bjune@medisin.uio.no; Fredrik Müller - fredrik.muller@rr-
research.no
* Corresponding author
Published: 21 June 2008
Received: 20 February 2008
Accepted: 21 June 2008
AIDS Research and Therapy 2008, 5:13
doi:10.1186/1742-6405-5-13
This article is available from: /content/5/1/13
? 2008 Nyombi et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Access to antiretroviral drugs for HIV-1 infection has increased in sub-Saharan
Africa (SSA) during the past few years. Mutations in the HIV-1 genome are often associated with
treatment failure as indicated by viral replication and elevated levels of virus in the blood. Mutations
conferring resistance to antiretroviral drugs are based on comparing gene sequences with
corresponding con
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