Progression to microalbuminuria in patients with type 1 diabetes a seven-year prospective study 英文参考文献.docVIP
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Progression to microalbuminuria in patients with type 1 diabetes a seven-year prospective study 英文参考文献
Cobasetal.DiabetologyMetabolicSyndrome2011,3:21
/content/3/1/21
DIABETOLOGY
METABOLIC SYNDROME
RESEARCH
OpenAccess
Progressiontomicroalbuminuriainpatientswith
type1diabetes:aseven-yearprospectivestudy
RobertaACobas1*,BráulioSantos2,PedroCBdaSilva1,RicardoNeves3andMariliaBGomes1
Abstract
Background:Thepresenceofmicroalbuminuriacanbeassociatedwithovertnephropathyandcardiovascular
diseaseinpatientswithtype1diabetes(T1D).Weaimedtodeterminetheincidenceandevaluatethebaseline
predictorsforthedevelopmentofmicroalbuminuriainpatientswithT1D.
Methods:Thisstudyisalongitudinalcohortstudyof122normoalbuminuricpatientswithT1Dwhowere
receivingroutineclinicalcareatbaseline.Adetailedmedicalhistorywastaken,andaphysicalexaminationwas
performedatbaseline.Allofthepatientswereregularlyexaminedfordiabetes-associatedcomplications.An
analysisofpredictorswasperformedusingtheCoxregression.
Results:Over6.81(3.59-9.75)yearsoffollow-up,50(41%)ofthepatientsdevelopedmicroalbuminuria.The
incidencedensitywas6.79/100peopleperyear(95%CI5.04-8.95),andthemicroalbuminuriadevelopedafter5.9
(2.44-7.76)and11(5-15)yearsoffollow-upanddiabetesduration,respectively.AfteranindividualCoxregression,
thebaselinevariablesassociatedwiththedevelopmentofmicroalbuminuriawereage,ageatdiagnosis,duration
ofdiabetes,systolicanddiastolicbloodpressure,fastingglycemia,bodymassindex(BMI),totalcholesteroland
triglycerideslevels,cholesterol/HDLratioandafamilyhistoryoftype2diabetes.AfteramultivariateCoxregression,
theonlyindependentfactorsassociatedwiththedevelopmentofmicroalbuminuriawereBMI[HR1.12(1.03-1.21)]
andcholesterol/HDLratio[HR1.32(1.05-1.67)].
Conclusions:AhigherBMIandcholesterol/HDLratioincreasedtheriskofdevelopingmicroalbuminuriainyoung
patientswithT1Dafterashortfollow-up.Bothriskfactorsaremodifiableandshouldbeidentifiedearlyand
followedclosely.
Keywords:DiabeticNephropathy,Microalbuminuria,Incidence,RiskFactors,Type1Diabetes
Background
developmentofcardiovasculardisease[5].Furthermore,
Type 1 diabetes (T1D) leads to
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