Promoter features related to tissue specificity as measured by Shannon entropy 英文参考文献.docVIP

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Promoter features related to tissue specificity as measured by Shannon entropy 英文参考文献.doc

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Promoter features related to tissue specificity as measured by Shannon entropy 英文参考文献

Open Access Re rch 2005SchugetVoal.lumesea6, Issue 4, Article R33 Promoter features related to tissue specificity as measured by Shannon entropy Jonathan Schug*, Winfried-Paul Schuller?, Claudia Kappen?, J Michael Salbaum?, Maja Bucan? and Christian J Stoeckert Jr* Addresses: *Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA. ?Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA. ?Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Correspondence: Jonathan Schug. E-mail: jschug@ Published: 29 March 2005 Received: 16 November 2004 Revised: 27 January 2005 Accepted: 16 February 2005 Genome Biology 2005, 6:R33 (doi:10.1186/gb-2005-6-4-r33) The electronic version of this article is the complete one and can be found online at /2005/6/4/R33 ? 2005 Schug et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PromoteraexrprparyAesagsniodnnofeaturesEmlSeTve-e-wbl aidsneerelatedddaindexeapnlyrtseitofissisetissue-specificoidofncpordmoamtpaoo.ntTeehrnsetwssexpressiontoasufdpcarriedyroemveateloutersdttinhhaathetdmisocontexttsint gguenisehofstsigenehssouw-sexpressionstpaeticsitfiiccaflrlyompatternssigunbiifqicuainintotutissues gen-esurveysdse.p/epndeusingnt varhumaniationsmicro-of Abstract Background: The regulatory mechanisms underlying tissue specificity are a crucial part of the development and maintenance of multicellular organisms. A genome-wide analysis of promoters in the context of gene-expression patterns in tissue surveys provides a means of identifying the general principles for these mechanisms. Results: We introduce a definition of tissue specificity based on Shannon entropy to rank hu