Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates glomerular fibrin deposition in a rat model of acute renal failure 英文参考文献.docVIP

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Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates glomerular fibrin deposition in a rat model of acute renal failure 英文参考文献.doc

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Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates glomerular fibrin deposition in a rat model of acute renal failure 英文参考文献

Available online /supplements/11/S4 Critical Care Volume 11 Suppl 4, 2007 Sepsis 2007 Paris, France, 26–29 September 2007 Published online: 26 September 2007 These abstracts are available online at /supplements/11/S4 ? 2007 BioMed Central Ltd P1 were performed with cytokine knockout mice, mice treated with low-dose LPS (1, 5 mg/kg) as a sepsis model without induction of hypotension, glucocorticoid-treated mice, and mice with renal artery clipping serving as a model for renal ischemia. Cytokine-mediated regulation of renal urea transporters during sepsis Christoph Schmidt, Klaus Hoecherl, Michael Bucher Anaesthesiology Department, Hospital of the University of Regensburg, Regensburg, Germany Results and discussion LPS-injected mice (10 mg/kg) presented with reduced glomerular filtration rate, fractional urea excretion and inner medulla osmolality associated with a marked decrease in expression of UT-A1, UT-A2, UT-A3, UT-A4 and UT-B (Figure 1). Similar alterations were observed after application of TNFα, IL-1β, IFNγ or IL-6. LPS-induced downregulation of urea transporters was not affected in knockout mice with deficient TNFα, IL-receptor-1, IFNγ or IL-6. Glucocorticoid treatment inhibited LPS-induced increases of tissue TNFα, IL-1β, IFNγ or IL-6 concentration, diminished LPS-induced renal dysfunction and attenuated the downregulation of renal urea transporters. Injection of low-dose LPS (1, 5 mg/kg) also led to renal dysfunction paralleled by a downregulation of renal urea transporters without alterations in blood pressure. Renal ischemia induced by renal artery clipping did not influence the expression of urea transporters. Critical Care 2007, 11(Suppl 4):P1 (doi: 10.1186/cc5980) Background The pathogenesis of endotoxemic tubular dys- function with failure in urine concentration is poorly understood. Urea plays an important role in the urinary co