Protein structure and function by the sea 英文参考文献.docVIP

/2002/3/4/reports/4008.1 Meeting report Protein structure and function by the sea Trevor Lithgow Address: Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Melbourne 3010, Australia. E-mail: t.lithgow@.au Published: 27 March 2002 GenomeBiology 2002, 3(4):reports4008.1–4008.2 The electronic version of this article is the complete one and can be found online at /2002/3/4/reports/4008 ? BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) running soon) will be solving a minimum of one or two A report on the 27th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia, 9-13 February 2002. new structures per week! Both the NYSGRC and RIKEN groups are focusing first on those proteins for which there is at least some hint of biomedical significance to knowing the structure. The Lorne protein structure and function meeting has a proud history of providing a relaxed atmosphere to ensure communication across scientific boundaries: with the waves crashing in the background and a glass of fine wine in hand, biochemists find themselves talking easily with cell biolo- gists and (even) spectroscopists. Bearing this in mind, the organizers of this year?s meeting set a theme based on the recent publication of the human genome sequence: stating that this information will ?change the way we formulate and address biological questions??, the challenge now being to ??address many of the hot issues awaiting protein science in the post-genome era??. Structural determination of protein complexes Other highlights of the meeting came in the session on key technologies. Werner Kühlbrandt (Max-Planck Institute, Grankfurt, Germany) presented the structures of several membrane protein complexes derived from analysis of two- dimensional translocase crystals, including the oligomeric SecYEG responsible for bacterial