Protective Effects of Celery Juice in Treatments with Doxorubicin 英文参考文献.docVIP

Molecules 2009, 14, 1627-1638; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effects of Celery Juice in Treatments with Doxorubicin Jovanka Kolarovic 1, Mira Popovic 2,* Momir Mikov 3, Radoslav Mitic 4 and Ljiljana , Gvozdenovic 5 1 Institute for Child and Youth Health Care of Vojvodina, Department of Hematology/Oncology, Novi Sad, Republic of Serbia 2 Department of Chemistry, Faculty of Science, University of Novi Sad, 21000 Novi Sad, Republic of Serbia, E-mail: popovic@ih.ns.ac.yu 3 Medical Faculty and Department of Pharmacology and Toxicology, University of Novi Sad, Republic of Serbia 4 Institute of Pharmacology, Faculty of Medicine, University of Pristina (Kosovska Mitrovica), Republic of Serbia 5 Department of Surgery, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Republic of Serbia * Author to whom correspondence should be addressed; E-mail: popovic@ih.ns.ac.yu; Tel.: +38 121 485 2770, Fax: +38 121 454 065. Received: 3 March 2009; in revised form: 14 April 2009/ Accepted: 23 April 2009 / Published: 24 April 2009 Abstract: The aim of this work was to investigate possible protective effect of celery juice in doxorubicin treatment. The following biochemical parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity in liver homogenate and blood hemolysate. We examined influence of diluted pure celery leaves and roots juices and their combinations with doxorubicine on analyzed biochemical parameters. Celery roots and leaves juices influenced the examined biochemical parameters and showed protective effects when applied with doxorubicine. Keywords: Celery juice; Doxorubicin; Reduced glutathione; Lipid peroxidation; Catalase.  Molecules 2009, 14 1628 1. Introduction Doxorubicin and other anthracyclines