Protective potential of 2-chloroadenosine in Klebsiella pneumoniae B5055 induced sepsis in BALBc mice 英文参考文献.docVIP

Available online /supplements/12/S5 Critical Care Volume 12 Suppl 5, 2008 Sepsis 2008 Granada, Spain, 19-22 November 2008 Published online: 18 November 2008 These abstracts are online at /supplements/12/S5 ? 2008 BioMed Central Ltd P1 P2 Medical simulation for severe sepsis: improving both factual knowledge and crisis management skills Protective potential of 2-chloroadenosine in Klebsiella pneumoniae B5055 induced sepsis in BALB/c mice Peter G Brindley Critical Care Medicine, University of Alberta, Edmonton, Canada Critical Care 2008, 12(Suppl 5):P1 (doi: 10.1186/cc7034) Vijay Kumar, Sanjay Chhibber Department of Microbiology, Panjab University, Chandigarh, India Critical Care 2008, 12(Suppl 5):P2 (doi: 10.1186/cc7035) Background The morbidity and mortality from severe sepsis depends largely on how quickly and comprehensively evidence- based therapies are administered. As such, a huge opportunity exists. However, optimal care requires not only factual knowledge, but also numerous practical strategies including the ability to recognize a disease, to identify impending crises, to communicate effectively, to run a team, to work under stress and to simul- taneously coordinate multiple tasks. Medical simulation offers a way to practice these essential crisis management skills, and with- out any risk to patients. Methods Following a didactic lecture on the key components of the Surviving Sepsis Campaign Guidelines, we trained 20 emer- gency medicine residents on a portable Laerdal Patient Simulator. Pre-programmed sepsis scenarios were developed following a needs assessment and modified Delphi technique. To maximize realism, this was performed in the acute care area of the Emergency Department and included a pre-briefed respiratory therapist and nurse. We videotaped resident performance and provided nonpunitive feedback, focusing on the comprehensive- n