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Prostaglandin E2 metabolism in rat brain Role of the blood-brain interfaces 英文参考文献
Cerebrospinal Fluid Research
BioMedCentral
Research
Open Access
Prostaglandin E2 metabolism in rat brain: Role of the blood-brain
interfaces
Eudeline Alix1, Charlotte Schmitt1, Nathalie Strazielle1,2 and Jean-
Fran?ois Ghersi-Egea*1
Address: 1INSERM, U 842, Lyon; Université de Lyon; Faculté de médecine Laennec, UMR-S842, Lyon, F69372, France and 2Brain-i, 34 Rue du Dr
Bonhomme, Lyon, F69008, France
Email: Eudeline Alix - eudeline.alix@chu-lyon.fr; Charlotte Schmitt - schmitt.charlotte@;
Nathalie Strazielle - strazielle@lyon.inserm.fr; Jean-Fran?ois Ghersi-Egea* - ghersi-egea@lyon.inserm.fr
* Corresponding author
Published: 4 March 2008
Received: 3 December 2007
Accepted: 4 March 2008
Cerebrospinal Fluid Research 2008, 5:5
doi:10.1186/1743-8454-5-5
This article is available from: /content/5/1/5
? 2008 Alix et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Prostaglandin E2 (PGE2) is involved in the regulation of synaptic activity and
plasticity, and in brain maturation. It is also an important mediator of the central response to
inflammatory challenges. The aim of this study was to evaluate the ability of the tissues forming the
blood-brain interfaces to act as signal termination sites for PGE2 by metabolic inactivation.
Methods: The specific activity of 15-hydroxyprostaglandin dehydrogenase was measured in
homogenates of microvessels, choroid plexuses and cerebral cortex isolated from postnatal and
adult rat brain, and compared to the activity measured in peripheral organs which are established
signal termination sites for prostaglandins. PGE2 metabolites produced ex vivo by choroid plexuses
were identified and quantified by HPLC coupled to radiochemi
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