ProSplicer a database of putative alternative splicing information derived from protein, mRNA and expressed sequence tag sequence data 英文参考文献.docVIP

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ProSplicer a database of putative alternative splicing information derived from protein, mRNA and expressed sequence tag sequence data 英文参考文献.doc

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ProSplicer a database of putative alternative splicing information derived from protein, mRNA and expressed sequence tag sequence data 英文参考文献

Open Access Software ProSplicer: a database of putative alternative splicing information derived from protein, mRNA and expressed sequence tag sequence data Hsien-Da Huang*, Jorng-Tzong Horng*?, Chau-Chin Lee? and Baw-Jhiune Liu? Addresses: *Department of Computer Science and Information Engineering, ?Department of Life Science, National Central University, Jung- Li City 320, Taiwan. ?Department of Computer Science and Engineering, Yuan-Ze University, Jung-Li City 320, Taiwan. Correspondence: Jorng-Tzong Horng. E-mail: horng@.tw Published: 14 March 2003 Received: 4 September 2002 Revised: 14 November 2002 Accepted: 24 January 2003 Genome Biology 2003, 4:R29 The electronic version of this article is the complete one and can be found online at /2003/4/4/R29 ? 2003 Huang et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract ProSplicer is a database of putative alternative splicing information derived from the alignment of proteins, mRNA sequences and expressed sequence tags (ESTs) against human genomic DNA sequences. Proteins, mRNA and ESTs provide valuable evidence that can reveal splice variants of genes. The alternative splicing information in the database can help users investigate the alternative splicing and tissue-specific expression of genes. Rationale genomic sequence. However, only SIM4 provides boundary information that can be used to postulate the splicing sites (donor sites and acceptor sites) when considering alternative splicing issues. Alternative splicing is a widely occurring and important mechanism for controlling the expression of cellular and viral genes. It changes the effects of a gene in different tissues and developmental states by generating distinct mRNA isoforms comp