Prostaglandin E Receptor Subtype EP3 Expression in Human Conjunctival Epithelium and Its Changes in Various Ocular Surface Disorders 英文参考文献.docVIP

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Prostaglandin E Receptor Subtype EP3 Expression in Human Conjunctival Epithelium and Its Changes in Various Ocular Surface Disorders 英文参考文献.doc

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Prostaglandin E Receptor Subtype EP3 Expression in Human Conjunctival Epithelium and Its Changes in Various Ocular Surface Disorders 英文参考文献

ProstaglandinEReceptorSubtypeEP3Expressionin HumanConjunctivalEpitheliumandItsChangesin VariousOcularSurfaceDisorders MayumiUeta1,2*,ChieSotozono1,NorihikoYokoi1,TsutomuInatomi1,ShigeruKinoshita1 1DepartmentofOphthalmology,KyotoPrefecturalUniversityofMedicine,Kyoto,Japan,2ResearchCenterforInflammationandRegenerativeMedicine,FacultyofLife andMedicalSciences,DoshishaUniversity,Kyoto,Japan Abstract Background:Inourearliergenome-wideassociationstudyonStevens-JohnsonSyndrome(SJS)anditsseverevariant,toxic epidermalnecrolysis(TEN),wefoundthatinJapanesepatientswiththesesevereocularsurfacecomplicationstherewasan associationwithprostaglandinEreceptor3(EP3)gene(PTGER3)polymorphisms.WealsoreportedthatEP3isdominantly expressed in the ocular surface-, especially the conjunctival epithelium, and suggested that EP3 in the conjunctival epithelium may down-regulate ocular surface inflammation. In the current study we investigated the expression of EP3 proteinintheconjunctivaofpatientswithvariousocularsurfacediseasessuchasSJS/TEN,chemicaleyeburns,Mooren’s ulcers,andocularcicatricialpemphigoid(OCP). Methodology/PrincipalFindings:Conjunctivaltissueswereobtainedfrompatientsundergoingsurgicalreconstructionof the ocular surface due to SJS/TEN, chemical eye burns, and OCP, and from patients with Mooren’s ulcers treated by resectionoftheinflammatoryconjunctiva.Thecontrolswerenearlynormalhumanconjunctivaltissuesacquiredatsurgery for conjunctivochalasis. We performed immunohistological analysis of the EP3 protein and evaluated the immunohisto- logicalstainingofEP3proteinintheconjunctivalepitheliumofpatientswithocularsurfacediseases.EP3wasexpressedin the conjunctival epithelium of patients with chemical eye burns and Mooren’s ulcer and in normal human conjunctival epithelium.However,itwasmarkedlydown-regulatedintheconjunctivalepitheliumofSJS/TENandOCPpatients. Conclusions:Wepositanassociationbetweenthedown-regulationofEP3inconjunctivalepitheliumandthepathogenesis and pathology of SJS/TEN and OC