Prospective Study of Chikungunya Virus Acute Infection in the Island of La Réunion during the 2005–2006 Outbreak 英文参考文献.docVIP

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Prospective Study of Chikungunya Virus Acute Infection in the Island of La Réunion during the 2005–2006 Outbreak 英文参考文献.doc

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Prospective Study of Chikungunya Virus Acute Infection in the Island of La Réunion during the 2005–2006 Outbreak 英文参考文献

ProspectiveStudyofChikungunyaVirusAcuteInfection intheIslandofLaRe′unionduringthe2005–2006 Outbreak FrederikStaikowsky1*,Franc?ois Talarmin1,PhilippeGrivard2,AbdelSouab1,IsabelleSchuffenecker3, KarinLeRoux2,MarcLecuit4,5,6.,AlainMichault2. 1EmergencyDepartment,Po?ledesSpe′cialite′sdel’Urgence,CentreHospitalierRe′gionaldeLaRe′union,GroupeHospitalierSudRe′union,SaintPierre,LaRe′union,France, 2DepartmentofMicrobiology,Po?ledebiologie,CentreHospitalierRe′gionaldeLaRe′union,GroupeHospitalierSudRe′union,SaintPierre,LaRe′union, France,3National ReferenceCenterforArboviruses,InstitutPasteur,Lyon,France,4InstitutPasteur,MicrobesandhostbarriersGroup,Paris,France,5Inserm,AvenirU604,Paris,France, 6Department of Infectious Diseases and Tropical Medicine, Paris Descartes University, Necker-Pasteur Center for Infectious Diseases, Ho?pital Necker-Enfants Malades, AssistancePublique-Ho?pitauxdeParis,Paris,France Abstract Background:Chikungunyavirus(CHIKV)isarecentlyre-emergedarthropodbornevirusresponsibleforamassiveoutbreak intheIndianOceanandIndia,andextendedtoSoutheastAsiaaswellasItaly.CHIKVhasadaptedtoAedesalbopictus ,an anthropophilicmosquitospecieswidelydistributedinAsia,Europe,AfricaandAmerica.Ourobjectivewastodeterminethe clinicalandbiologicalfeaturesofpatientsattheacutephaseofCHIKVinfection. Methods and Findings: A prospective study enrolled 274 consecutive patients with febrile arthralgia recorded at the EmergencyDepartmentoftheGroupeHospitalierSud-Re′unionbetweenMarchandMay2006.Threegroupsweredefined: one group of 180 viremic patients (positive CHIKV RT-PCR), one group of 34 patients with acute post-viremic infection (negative CHIKV RT-PCR, positive anti-CHIKV IgM and negative IgG), and one group of 46 uninfected patients (negative CHIKV RT-PCR, anti-CHIKV IgM and IgG). Bivariate analyses of clinical and biological features between groups were performed.PatientswithCHIKVviremiapresentedtypicallywithasymmetricalbilateralpolyarthralgia(96.5%)affectingthe lower(98%)