Prolonged mechanical ventilation in critically ill patients epidemiology, outcomes and modelling the potential cost consequences of establishing a regional weaning unit 英文参考文献.docVIP
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Prolonged mechanical ventilation in critically ill patients epidemiology, outcomes and modelling the potential cost consequences of establishing a regional weaning unit 英文参考文献
LoneandWalshCriticalCare2011,15:R102
/content/15/2/R102
RESEARCH
OpenAccess
Prolongedmechanicalventilationincriticallyill
patients:epidemiology,outcomesandmodelling
thepotentialcostconsequencesofestablishinga
regionalweaningunit
NazirILone1* andTimothySWalsh2
Abstract
Introduction:Thenumberofpatientsrequiringprolongedmechanicalventilation(PMV)islikelytoincrease.
Transferringpatientstospecialisedweaningunitsmayimproveoutcomesandreducecosts.Theaimofthisstudy
wastoestablishtheincidenceandoutcomesofPMVinaUKadministrativehealthcareregionwithouta
dedicatedweaningunit,andmodelthepotentialimpactofestablishingadedicatedweaningunit.
Methods:Aretrospectivecohortstudywasundertakenusingadatabaseofadmissionstothreeintensivecare
units(ICU)inaUKregionfrom2002to2006.Usinga21daycut-offtodefinePMV,incidencewascalculatedusing
allICUadmissionsandventilatedICUadmissionsasdenominators.OutcomesforthePMVcohort(mortalityand
hospitalresourceuse)werecomparedwiththenon-PMVcohort.LengthofICUstaybeyond21dayswasusedto
modeltheeffectofestablishingaweaningunitintermsofunitoccupancyrates,admissionrefusalrates,and
healthcarecosts.
Results:Outof8290ICUadmissionepisodes,7848wereincludedintheanalysis.Mechanicalventilationwas
requiredduring5552admissionepisodes,ofwhich349requiredPMV.TheincidenceofPMVwas4.4per100ICU
admissions,and6.3per100ventilatedICUadmissions.PMVpatientsused29.1%ofallgeneralICUbeddays,spent
longerinhospitalafterICUdischargethannon-PMVpatients(median17vs7days,P0.001)andhadhigher
hospitalmortality(40.3%vs33.8%,P=0.02).Fortheregion,inwhichabout70PMVpatientsweretreatedeachyear,
aweaningunitwithacapacityofthreebedsappearedmostcostefficient,resultinginanoccupancyrateof73%,
admissionrefusalrateat21daysof36%,andpotentialcostsavingof£344,000(€418,000)usingUKhealthcaretariffs.
Conclusions:OneineverysixteenventilatedpatientsrequiresPMVinourregionandthisgroupuseasubstantial
amountofhealthcareresource.Establishingaweaningunitwouldpotentiallyreduceacutebedoccupancyby8-
10%andcouldreduceoveralltrea
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