Prognostic Impact of FoxP3+ Regulatory T Cells in Relation to CD8+ T Lymphocyte Density in Human Colon Carcinomas 英文参考文献.docVIP

下载本文档

12
0
约 10页
2017-05-13 发布于上海
举报
版权申诉

Prognostic Impact of FoxP3+ Regulatory T Cells in Relation to CD8+ T Lymphocyte Density in Human Colon Carcinomas 英文参考文献.doc

1、本文档共10页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

PrognosticImpactofFoxP3RegulatoryTCellsinRelationtoCD8TLymphocyteDensityinHumanColonCarcinomas英文参考文献

PrognosticImpactofFoxP3+RegulatoryTCellsin RelationtoCD8+TLymphocyteDensityinHumanColon Carcinomas HarryH.Yoon1,JaredM.Orrock2,NathanR.Foster3,DanielJ.Sargent3,ThomasC.Smyrk2, FrankA.Sinicrope1,4 * 1DepartmentofOncology,MayoClinic,Rochester,Minnesota,UnitedStatesofAmerica,2DepartmentofLaboratoryMedicineandPathology,MayoClinic,Rochester, Minnesota,UnitedStatesofAmerica,3DepartmentofHealthSciencesResearch MayoClinic,Rochester,Minnesota,UnitedStatesofAmerica,4DepartmentofMedicine, MayoClinic,Rochester,Minnesota,UnitedStatesofAmerica Abstract Background:T-lymphocyteinfiltrationintocoloncarcinomascaninfluenceclinicaloutcome,andinteractionsamongTcell subsetsmaybemoreinformativethaneithersubsetalone.Ourobjectivewastoexaminetheprognosticimpactoftumor- infiltratingFoxP3+regulatoryTcells(Tregs)inrelationtocytotoxicCD8 Tlymphocytesinpatientswithcoloncarcinomas characterizedbyDNAmismatchrepair(MMR)statuswhoparticipatedinadjuvantchemotherapytrials. + Methods: FoxP3+ and CD8+ densities in tumor epithelial and stromal compartments were analyzed by immunohisto- chemistryandquantifiedinresected,stageIIandIIIcoloniccarcinomas(N=216).Immunemarkerdensitywasdichotomized atthemedianandcategorizedashighvslow.MMRstatuswasclassifiedasMMRdeficient(dMMR)orproficient(pMMR).Cox modelswereadjustedforage,stage,andtumorgrade. Results:ThedensityofFoxP3+infiltrationwassimilarintumorstromaandepithelia,whereasCD8+washigherinstroma. TheprognosticimpactofFoxP3+andCD8+Tcellinfiltrationwasstrongerinstromavsepithelia,andthedensityofeach marker in stroma was independently associated with improved overall survival (OS). However, the impact of FoxP3+ on survival was dependent upon CD8+ density (P interaction =.040). Among CD8+low tumors, FoxP3+high cases had significantlyimprovedOScomparedtoFoxP3+ casesafteradjustmentforcovariates(hazardratio0.43;95%confidence low interval0.19to0.95;P=.030).Incontrast,FoxP3+wasnotprognosticamongCD8+hightumors.FoxP3+remainedprognostic in CD8+low tumors after furt