Prognostic factors for low birthweight repetition in successive pregnancies a cohort study 英文参考文献.docVIP
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Prognostic factors for low birthweight repetition in successive pregnancies a cohort study 英文参考文献
Sclowitzetal.BMCPregnancyandChildbirth2013,13:20
/1471-2393/13/20
RESEARCH ARTICLE
OpenAccess
Prognosticfactorsforlowbirthweightrepetition
insuccessivepregnancies:acohortstudy
IandoraKrolowTimmSclowitz,InáSSantos*,MarlosRodriguesDomingues,AliciaMatijasevich
andAluísioJDBarros
Abstract
Background:Toidentifyprognosticfactorsassociatedwithrecurrenceoflowbirthweight(LBW)insuccessive
gestations,astudywascarriedoutwithasubsampleofmothersenrolledinthe2004PelotasBirthCohort.
Methods:Datawerecollectedbyhospital-basedinterviews.Newbornswereweighedandmeasured.Gestational
agewasdefinedaccordingtothedateoflastmenstrualperiod,ultra-soundscanbeforethe20thweekof
pregnancyortheDubowitzmethod.MotherswhoreportedatleastoneLBWnewborninthetwoprevious
gestationswereincluded.Prevalenceratios(PR)and95%confidenceintervalswereestimatedfromPoisson
Regression.Allestimateswereadjustedforparity.
Results:Atotalof4558birthswereidentifiedin2004,and565metinclusioncriteria,outofwhich86(15.2%)
repeatedLBWin2004.AmongmotherswithtwoLBWbabiesbefore2004,47.9%presentedLBWrecurrence.
Belongingtothehighestsocio-economicstratum(PR0.89;0.01-0.46)andgaining≥10kgduringpregnancy(PR
0.09;0.01-0.77)wereprotectiveagainstLBWrecurrence.HigherriskofLBWrecurrencewasobservedamong
motherswithhigherparity(≥3previousdeliveries;PR=1.93;95%CI1.23-3.02);whohadgivenbirthtoaprevious
pretermbaby(PR=4.01;2.27-7.10);whodeliveredafemalenewbornincurrentgestation(PR=2.61;1.45-4.69);and
thathadnotreceivedadequateantenatalcare(PR=2.57;1-37-4.81).
Conclusion:Improvedqualityofantenatalcareandadequatematernalweightgainduringpregnancymaybe
feasiblestrategiestopreventLBWrepetitioninsuccessivepregnancies.
Keywords:Prognosticfactors,Lowbirthweightrecurrence,Lowbirthweight,Preterm,Antenatalcare
Background
andgestationalages,suggestingtheexistenceofcommon
Low birthweight (LBW) defined as birth weight lower underlyingriskfactorsorgeneticcharacteristicsthatplay
than 2500 grams is an important infant mortality and aroleinthecausationofsuchoutcome
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