Protein structure protection commits gene expression patterns 英文参考文献.docVIP

Open Access Re rch 2008ChenetVoal.lumesea9, Issue 7, Article R107 Protein structure protection commits gene expression patterns Jianping Chen*, Han Liang? and Ariel Fernández*?§ Addresses: *Program in Applied Physics, Rice Quantum Institute, Rice University, Houston, TX 77005, USA. ?Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA. ?Department of Bioengineering, Rice University, Houston, TX 77005, USA. §Department of Computer Science, University of Chicago, Chicago, IL 60637, USA. Correspondence: Ariel Fernández. Email: arifer@ Published: 7 July 2008 Received: 19 May 2008 Revised: 6 July 2008 Accepted: 7 July 2008 Genome Biology 2008, 9:R107 (doi:10.1186/gb-2008-9-7-r107) The electronic version of this article is the complete one and can be found online at /2008/9/7/R107 ? 2008 Chen et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ProteinyepasAt apnrstructuredotheuommaicna.regulatesss/opciationexpressionstudy between protein three-dimensional structure and transcriptional and post-transcriptional regulation in Abstract Background: Gene co-expressions often determine module-defining spatial and temporal concurrences of proteins. Yet, little effort has been devoted to tracing coordinating signals for expression correlations to the three-dimensional structures of gene products. Results: We performed a global structure-based analysis of the yeast and human proteomes and contrasted this information against their respective transcriptome organizations obtained from comprehensive microarray data. We show that protein vulnerability quantifies dosage sensitivity for metabolic adaptation phases and tissue-specific patterns of mRNA expression, determining