Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis 英文参考文献.docVIP

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Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis 英文参考文献.doc

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Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis 英文参考文献

o PL SMEDICINE ProteomicProfilingoftheAmnioticFluid toDetectInflammation,Infection, andNeonatalSepsis Catalin S.Buhimschi1*,Vineet Bhandari2,Benjamin D.Hamar1,Mert-Ozan Bahtiyar1,2,Guomao Zhao1, Anna K.Sfakianaki1,Christian M. Pettker1,Lissa Magloire1,Edmund Funai1,Errol R.Norwitz1,Michael Paidas1, Joshua A.Copel1,Carl P.Weiner3,Charles J.Lockwood1,Irina A.Buhimschi1 1DepartmentofObstetrics,GynecologyandReproductiveScience,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,UnitedStatesofAmerica,2Departmentof Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, 3 Department of Obstetrics and Gynecology,UniversityofKansasSchoolofMedicine,KansasCity,Kansas,UnitedStatesofAmerica ABSTRACT Funding:Thestudywasfundedbya grantfromNationalInstitutesofHealth RO1HD047321(IAB)andRO3HD50249 (CSB).Thefundershadnoroleinstudy design,datacollectionandanalysis, decisiontopublish,orpreparationof themanuscript. Background Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterineinflammation.Wesoughttovalidateprospectivelytheclinicalutilityofonesuch proteomicprofile,theMassRestricted(MR)score. CompetingInterests:Dr.IrinaA. Buhimschiisnamedco-inventorona pendingpatentapplicationrelatedto theuseofproteomicsanalysisof amnioticfluidfordiagnosisofpreterm MethodsandFindings delivery.Neithershenoranyofthe authorsservedasconsultantsor We enrolled 169 consecutive women with singleton pregnancies admitted with preterm receivedresearchfundsfromathird partyinterestedinbiomarkerdiscovery includingCiphergenBiosystems. labor or preterm premature rupture of membranes. All women had a clinically indicated amniocentesis to rule out intra-amniotic infection. A proteomic fingerprint (MR score) was generated from fresh samples of amniotic fluid using surface-enhanced laser desorption ionization(SELDI)massspectrometry.PresenceorabsenceofthebiomarkersoftheMRscore was interpreted in