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Proteomic view of mitochondrial function 英文参考文献
Minireview
Proteomic view of mitochondrial function
Kai Stefan Dimmer and Doron Rapaport
Address: Interfakult?res Institut für Biochemie, Hoppe-Seyler-Strasse, University of Tübingen, 72076 Tübingen, Germany.
Correspondence: Doron Rapaport. Email: doron.rapaport@uni-tuebingen.de
Published: 29 February 2008
Genome Biology 2008, 9:209 (doi:10.1186/gb-2008-9-2-209)
The electronic version of this article is the complete one and can be
found online at /2008/9/2/209
? 2008 BioMed Central Ltd
Abstract
Genomic and proteomic studies have identified hundreds of proteins from mitochondria. A
recent study has added a functional twist to these systematic approaches and identified novel
mitochondrial modifiers and regulators.
Mitochondria are ubiquitous and essential organelles in all
eukaryotes and have many functions other than their main
task of producing ATP. Besides the production of energy by
cellular respiration, mitochondria host the tricarboxylic acid
cycle (TCA cycle) and the β-oxidation of fatty acids. In
addition, anabolic processes such as the biosynthesis of heme,
amino acids and lipids take place inside the organelle.
Mitochondria are also pivotal for the production of iron-sulfur
clusters for the entire eukaryotic cell [1]. Altogether, these
organelles are involved in a myriad of different processes, as
summarized in Figure 1. The shape of the mitochondrial
network is sustained by three basic processes - fusion, fission
and active transport of the organelle along the cytoskeleton.
functions but also from their crucial role in cellular
signaling. In cooperation with the endoplasmic reticulum,
mitochondria
play an important role in the cellular
homeostasis of Ca2+ [3]. They also have a major role in
triggering apoptosis, as several different pro-apoptotic
signals are integrated and interpreted at the mitocho
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