Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients Skin Which Are Normalized by Kidney-Pancreas Transplantation 英文参考文献.docVIP

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Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients Skin Which Are Normalized by Kidney-Pancreas Transplantation 英文参考文献.doc

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Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients Skin Which Are Normalized by Kidney-Pancreas Transplantation 英文参考文献

ProteomicsRevealsNovelOxidativeandGlycolytic MechanismsinType1DiabeticPatients’SkinWhichAre NormalizedbyKidney-PancreasTransplantation FrancoFolli1*.,ValeriaGuzzi2.,LuciaPerego2.,DawnK.Coletta3,GiovannaFinzi4,ClaudiaPlacidi4, StefanoLaRosa4,CarloCapella4,CarloSocci5,DavideLauro6,DevjitTripathy1,ChristopherJenkinson1, RitaParoni2,ElenaOrsenigo5,GiulianaCighetti6,LuisaGregorini2,CarloStaudacher5,AntonioSecchi7, AngelaBachi8,MichaelBrownlee9,PaoloFiorina10* 1DiabetesDivision,DepartmentofMedicine,UniversityofTexasHealthScienceCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica,2Departmentof Medicine,Surgery,DentalScience,Universita` degliStudidiMilano,Milan,Italy,3CenterforMetabolicBiology,SchoolofLifeSciences,ArizonaStateUniversity,Tempe, Arizona,UnitedStatesofAmerica,4DepartmentofPathology,OspedalediCircoloandDepartmentofHumanMorphology,UniversityofInsubria,Varese,Italy,5Surgery Department,SanRaffaeleScientificInstitute,Milan,Italy,6DepartmentofClinicalSciences‘‘LuigiSacco’’,Universita` degliStudidiMilano,Milan,Italy,7Departmentof Medicine, San Raffaele Scientific Institute, Milan, Italy, 8Department of Oncology, Universita` Vita e Salute-San Raffaele, Milan, Italy, 9Departments of Medicine and Pathology, Albert Einstein College of Medicine, New York, New York, United States of America, 10Transplantation Research Center/Nephrology Division, Children’s Hospital/BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background: In type 1 diabetes (T1D) vascular complications such as accelerated atherosclerosis and diffused macro-/ microangiopathyarelinkedtochronichyperglycemiawithamechanismthatisnotyetwellunderstood.End-stagerenal disease(ESRD) worsens most diabeticcomplications, particularly, therisk ofmorbidity andmortality from cardiovascular diseaseisincreasedseveralfold. MethodsandFindings:WeevaluatedproteinregulationandexpressioninskinbiopsiesobtainedfromT1Dpatientswith and without ESRD, to identify path