Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis 英文参考文献.docVIP

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Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis 英文参考文献.doc

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Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis 英文参考文献

Prox1IsRequiredforGranuleCellMaturationand IntermediateProgenitorMaintenanceDuringBrain Neurogenesis AlfonsoLavado1,OlegV.Lagutin1,LionelM.L.Chow2,SuzanneJ.Baker2,GuillermoOliver1* 1DepartmentofGeneticsTumorCellBiology,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,2DepartmentofDevelopmental Neurobiology,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica Abstract Thedentategyrushasanimportantroleinlearningandmemory,andadultneurogenesisinthesubgranularzoneofthe dentategyrusmayplayaroleintheacquisitionofnewmemories.ThehomeoboxgeneProx1isexpressedinthedentate gyrusduringembryonicdevelopmentandadultneurogenesis.HereweshowthatProx1isnecessaryforthematurationof granulecellsinthedentategyrusduringdevelopmentandforthemaintenanceofintermediateprogenitorsduringadult neurogenesis.WealsodemonstratethatProx1-expressingintermediateprogenitorsarerequiredforadultneuralstemcell self-maintenanceinthesubgranularzone;thus,wehaveidentifiedapreviouslyunknownnon-cellautonomousregulatory feedback mechanism that controls adult neurogenesis in this region of the mammalian brain. Finally, we show that the ectopicexpressionofProx1inducesprematuredifferentiationofneuralstemcells. Citation:LavadoA,LagutinOV,ChowLML,BakerSJ,OliverG(2010)Prox1IsRequiredforGranuleCellMaturationandIntermediateProgenitorMaintenance DuringBrainNeurogenesis.PLoSBiol8(8):e1000460.doi:10.1371/journal.pbio.1000460 AcademicEditor:TheoD.Palmer,StanfordUniversity,UnitedStatesofAmerica ReceivedMarch9,2010;AcceptedJuly9,2010;PublishedAugust17,2010 Copyright: ? 2010 Lavado et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisprojectwassupportedinpartbyNationalInstitutesofHealthgrantsR01-HL073402,P01-CA096832,CancerCenterSupportCA-21765,andthe AmericanLebaneseSyrianAssociatedCharities(ALSAC).Thef