Pseudomonas aeruginosa contamination of mouth swabs during production causing a major outbreak 英文参考文献.docVIP

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Pseudomonas aeruginosa contamination of mouth swabs during production causing a major outbreak 英文参考文献.doc

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Pseudomonas aeruginosa contamination of mouth swabs during production causing a major outbreak 英文参考文献

Annals of Clinical Microbiology and Antimicrobials BioMedCentral Research Open Access Pseudomonas aeruginosa contamination of mouth swabs during production causing a major outbreak Bj?rn G Iversen*1, Hanne-Merete Eriksen1, Gjermund B?2, Kristian Hagestad3, Trond Jacobsen4, Eva Engeset1, J?rgen Lassen1 and Preben Aavitsland1 Address: 1Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, 2The Norwegian Food Safety Authority, district office of Vest-Agder, Kristiansand, Norway, 3The Norwegian Board of Health in the County of Vest-Agder, Kristiansand, Norway and 4St. Olavs Hospital, Trondheim, Norway Email: Bj?rn G Iversen* - bjiv@fhi.no; Hanne-Merete Eriksen - hmer@fhi.no; Gjermund B? - Gjermund.Bo@mattilsynet.no; Kristian Hagestad - kha@fmva.no; Trond Jacobsen - trond.jacobsen@stolav.no; Eva Engeset - even@fhi.no; J?rgen Lassen - jola@fhi.no; Preben Aavitsland - praa@fhi.no * Corresponding author Published: 13 March 2007 Received: 21 December 2006 Accepted: 13 March 2007 Annals of Clinical Microbiology and Antimicrobials 2007, 6:3 doi:10.1186/1476-0711-6-3 This article is available from: /content/6/1/3 ? 2007 Iversen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contamination possible, in order to prevent future outbreaks. Methods: Environmental investigation with microbiological examination of production, ingredients and product