Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo 英文参考文献.docVIP

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Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo 英文参考文献.doc

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Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo 英文参考文献

PsoriasisRegressionAnalysisofMHCLociIdentifies SharedGeneticVariantswithVitiligo Kun-JuZhu1,2.,Yong-MeiLv1,2.,Xian-YongYin1,2,Zai-XingWang1,2,Liang-DanSun1,2,Su-MinHe1,2 ,Hui Cheng1,2,Da-YanHu1,2,ZhengZhang1,2,YangLi1,2,Xian-BoZuo1,2,You-WenZhou1,2,3,SenYang1,2 XingFan1,2*,Xue-JunZhang1,2*,Feng-YuZhang1,2 , * 1InstituteofDermatologyandDepartmentofDermatologyatNo.1Hospital,AnhuiMedicalUniversity,Hefei,Anhui,China,2TheStateKeyLaboratoryIncubationBaseof Dermatology,Hefei,Anhui,China,3TheStateDepartmentofDermatologyandSkinScience,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada Abstract Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1locus(6q21)hasbeenstronglyassociatedwithpsoriasis;however,itisdifficulttoidentifyadditionalindependent associationduetostronglinkagedisequilibriumintheMHCregion.Weperformedstepwiseregressionanalysesofmore than3,000SNPsintheMHCregiongenotypedusingHuman610-Quad(Illumina)in1,139caseswithpsoriasisand1,132 controlsofHanChinesepopulationtosearchforadditionalindependentassociation.Withfourregressionmodelsobtained, twoSNPsrs9468925inHLA-C/HLA-Bandrs2858881inHLA-DQA2wererepeatedlyselectedinallmodels,suggestingthat multiplelocioutsidePSOR1locuswereassociatedwithpsoriasis.Moreimportantlywefindthatrs9468925inHLA-C/HLA-Bis associatedwithbothpsoriasisandvitiligo,providingfirstimportantevidencethattwomajorskindiseasesshareacommon geneticlocusintheMHC,andabasisforelucidatingthemolecularmechanismofskindisorders. Citation:ZhuK-J,LvY-M,YinX-Y,WangZ-X,SunL-D,etal.(2011)PsoriasisRegressionAnalysisofMHCLociIdentifiesSharedGeneticVariantswithVitiligo.PLoS ONE6(11):e23089.doi:10.1371/journal.pone.0023089 Editor:SusanKovats,OklahomaMedicalResearchFoundation,UnitedStatesofAmerica ReceivedMarch19,2011;AcceptedJuly5,2011;PublishedNovember18,2011 Copyright:?2011Zhuetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,d