Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins 英文参考文献.docVIP

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2017-05-13 发布于上海
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Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins 英文参考文献.doc

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Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins 英文参考文献

Nilssonetal.GenomeBiology2011,12:R65 /2011/12/7/R65 RESEARCH OpenAccess Proteome-wideevidenceforenhancedpositive Darwinianselectionwithinintrinsicallydisordered regionsinproteins JohanNilsson1,MatsGrahn1andAnthonyPHWright1,2* Abstract Background:Understandingtheadaptivechangesthatalterthefunctionofproteinsduringevolutionisan importantquestionforbiologyandmedicine.Theincreasingnumberofcompletelysequencedgenomesfrom closelyrelatedorganisms,aswellasindividualswithinspecies,facilitatessystematicdetectionofrecentselection eventsbymeansofcomparativegenomics. Results:Wehaveusedgenome-widestrain-specificsinglenucleotidepolymorphismdatafrom64strainsof buddingyeast(SaccharomycescerevisiaeorSaccharomycesparadoxus)todeterminewhetheradaptivepositive selectioniscorrelatedwithproteinregionsshowingpropensityfordifferentclassesofstructureconformation.Data fromphylogeneticandpopulationgeneticanalysisof3,746genealignmentsconsistentlyshowsasignificantly higherdegreeofpositiveDarwinianselectioninintrinsicallydisorderedregionsofproteinscomparedtoregionsof alphahelix,betasheetortertiarystructure.Evidenceofpositiveselectionissignificantlyenrichedinclassesof proteinswhosefunctionsandmolecularmechanismscanbecoupledtoadaptiveprocessesandtheseclassestend tohaveahigheraveragecontentofintrinsicallyunstructuredproteinregions. Conclusions:Wesuggestthatintrinsicallydisorderedproteinregionsmaybeimportantfortheproductionand maintenanceofgeneticvariationwithadaptivepotentialandthattheymaythusbeofcentralsignificanceforthe evolvabilityoftheorganismorcellinwhichtheyoccur. Background majorityofmutationstobeeitherdeleteriousorneutral, Understanding the process of adaptation is of central recent years haveseenasharp increase inpublications importance formanybiological questions, suchashow indentifyingtheactionofpositiveDarwinianselectionon speciesrespondtoclimate changes,pathogens orother genesinvariousspecies[2].Therapidlyincreasingnum- environmentalperturbations,aswellforthemechanisms ber of com