Pulmonary capillary pressure in pulmonary hypertension 英文参考文献.docVIP

Available online /content/9/2/R132 Research Open Access April 2005 Vol 9 No 2 Pulmonary capillary pressure in pulmonary hypertension Rogerio Souza, Marcelo Britto Passos Amato, Sergio Eduardo Demarzo, Daniel Deheinzelin, Carmen Silvia Valente Barbas, Guilherme Paula Pinto Schettino and Carlos Roberto Ribeiro Carvalho Pulmonary Division, Respiratory ICU – Heart Institute (InCor), University of S?o Paulo Medical School, S?o Paulo, Brazil Corresponding author: Rogerio Souza, rgrsz@.br Received: 2 September 2004 Critical Care 2005, 9:R132-R138 (DOI 10.1186/cc3038) This article is online at: /content/9/2/R132 Revisions requested: 2 November 2004 Revisions received: 22 November 2004 Accepted: 7 December 2004 ? 2005 Souza et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/ licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Published: 11 February 2005 Abstract Introduction Pulmonary capillary pressure (PCP), together with the time constants of the various vascular compartments, define the dynamics of the pulmonary vascular system. Our objective in the present study was to estimate PCPs and time constants of the vascular system in patients with idiopathic pulmonary arterial hypertension (IPAH), and compare them with these measures in patients with acute respiratory distress syndrome (ARDS). Methods We conducted the study in two groups of patients with pulmonary hypertension: 12 patients with IPAH and 11 with ARDS. Four methods were used to estimate the PCP based on monoexponential and biexponential fitting of pulmonary artery pressure decay curves. Results PCPs in the IPAH group were considerably greater than those in the ARDS group. The PCPs measured using the four methods also differed significantly, suggesting that each method measures the pressure at