Pumpkin (Cucurbita moschata) Fruit Extract Improves Physical Fatigue and Exercise Performance in Mice 英文参考文献.docVIP
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Pumpkin (Cucurbita moschata) Fruit Extract Improves Physical Fatigue and Exercise Performance in Mice 英文参考文献
Molecules 2012, 17, 11864-11876; doi:10.3390/molecules171011864
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Pumpkin (Cucurbita moschata) Fruit Extract Improves Physical
Fatigue and Exercise Performance in Mice
Shih-Yi Wang 1,?, Wen-Ching Huang 2,?, Chieh-Chung Liu 3,?, Ming-Fu Wang 1,?, Chin-Shan Ho 4,
Wen-Pei Huang 4, Chia-Chung Hou 4, Hsiao-Li Chuang 5,* and Chi-Chang Huang 4,6,*
1
Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan
2
Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University,
Taoyuan 33301, Taiwan
3
Department of Physical Education, Yuanpei University, Hsinchu 30015, Taiwan
4
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
5
National Laboratory Animal Center, National Applied Research Laboratories, Taipei 11529, Taiwan
6
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
?
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed;
E-Mails: p650214@.tw (H.-L.C.); john5523@.tw (C.-C.H.);
Tel.: +886-3-328-3201 (ext. 2619) (C.-C.H.); Fax: +886-3-328-0592 (C.-C.H.).
Received: 6 August 2012; in revised form: 8 September 2012 / Accepted: 8 October 2012 /
Published: 9 October 2012
Abstract: Pumpkin (Cucurbita moschata) is a popular and nutritious vegetable consumed
worldwide. The overall purpose of this study was to evaluate the effects of C. moschata
fruit extract (CME) on anti-fatigue and ergogenic functions following physiological
challenges. Male ICR mice from four groups designated vehicle, CME-50, CME-100 and
CME-250, respectively (n = 8 per group in each test) were orally administered CME for 14
days at 0, 50, 100 and 250 mg/kg/day. The anti-fatigue activity and exercise performance
were evaluated using exhaustive swimming time, forelimb grip strength, as well as levels
of plasma lactate, ammonia, glucose, a
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