Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport 英文参考文献.docVIP

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Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport 英文参考文献.doc

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Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport 英文参考文献

Williamsetal.EJNMMIResearch2012,2:6 /content/2/1/6 ORIGINAL RESEARCH OpenAccess Quantitationofglucoseuptakeintumorsby dynamicFDG-PEThaslessglucosebiasandlower variabilitywhenadjustedforpartialsaturationof glucosetransport Simon-PeterWilliams1*,JudithEFlores-Mercado1,RuedigerEPort2andThomasBengtsson3* Abstract Background:Aretrospectiveanalysisofestimatesoftumorglucoseuptakefrom1,192dynamic2-deoxy-2-(18F) fluoro-D-glucose-positron-emissiontomography[FDG-PET]scansshowedstrongcorrelationsbetweenblood glucoseandboththeuptakerateconstant[Ki]andthemetabolicrateofglucose[MRGluc],hinderingthe interpretationofPETscansacquiredunderconditionsofalteredbloodglucose.Wesoughtamethodtoreduce thisglucosebiaswithoutincreasingthebetween-subjectortest-retestvariabilityanddidthisbyconsideringthat tissueglucosetransportisasaturableyetunsaturatedprocessbestdescribedasanonlinearfunctionofglucose levels. Methods:Patlak-GjeddeanalysiswasusedtocomputeKifrom30-mindynamicPETscansintumor-bearingmice. MRGlucwascalculatedbyfactoringinthebloodglucoselevelandalumpedconstantequaltounity.Alternatively, weassumedthatglucoseconsumptionissaturableaccordingtoMichaelis-Mentenkineticsandestimateda hypotheticalmaximumrateofglucoseconsumption[MRGlucMAX]bymultiplyingKiand(KM +[glucose]),whereKM isahalf-saturationMichaelisconstantforglucoseuptake.Resultswerecomputedfor112separatestudiesof8to 12scanseach;test-reteststatisticsweremeasuredinasuitablesubsetof201mice. Results:AKM valueof130mg/dLwasdeterminedfromthedatabasedonminimizingtheaveragecorrelation betweenbloodglucoseandtheuptakemetric.UsingMRGlucMAX resultedinthefollowingbenefitscomparedto usingMRGluc:(1)themediancorrelationwithbloodglucosewaspracticallyzero,andyet(2)thetest-retest coefficientofvariation[COV]wasreducedby13.4%,and(3)thebetween-animalCOVswerereducedby15.5%.In statisticallyequivalentterms,achievingthesamereductioninbetween-animalCOVwhileusingthetraditional MRGlucwouldrequirea40%increaseinsamplesize. Conclusions:MRGlucappearedtoove