Recent Applications of Polymer Supported Organometallic Catalysts in Organic Synthesis 英文参考文献.docVIP

Molecules 2010, 15, 6306-6331; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Recent Applications of Polymer Supported Organometallic Catalysts in Organic Synthesis Nina Kann Organic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-41296 G?teborg, Sweden; E-Mail: kann@chalmers.se; Tel.: +46-31-772-3070; Fax: +46-31-772-3858 Received: 18 June 2010; in revised form: 18 August 2010 / Accepted: 2 September 2010 / Published: 7 September 2010 Abstract: Recent developments concerning the application of polymer supported organometallic reagents in solid phase synthesis are reviewed, with a special focus on methodology for carbon-carbon formation. Examples of reactions that are covered include the classical Suzuki, Sonogashira and Heck coupings, but also aryl amination, epoxide opening, rearrangements, metathesis and cyclopropanation. Applications in the field of asymmetric synthesis are also discussed. Keywords: polymer supported; organometallic; solid phase synthesis; cross-coupling; metathesis; allylic substitution; transfer hydrogenation; aryl amination Abbreviations: acac: acetylacetonato; AIBN: azoisobutyronitrile; BSA: N,O-bis(tri- methyl silyl)-acetamide; DMA: N,N-dimethylacetamide; DPEN: 1,2-diphenyl- ethylenediamine; DVB: divinylbenzene; NHC: N-heterocyclic carbene; PEG: polyethylene glycol; PHOX: diphenylphosphinooxazoline; PS: polystyrene; TBAA: tetrabutyl- ammonium acetate; TEMPO: 2,2,6,6-tetramethyl-piperidin-1-oxyl; TOF: turnover frequency; TON: turnover number 1. Introduction This review covers literature concerning the application of polymer bound organometallic reagents in organic synthesis from 2007 until May 2010; for earlier reports in this area we refer to comprehensive reviews covering the time up to 2007 [1-8]. Likewise, solid p