Recent advances in the investigation of curcuminoids 英文参考文献.docVIP

Chinese Medicine BioMedCentral Review Open Access Recent advances in the investigation of curcuminoids Hideji Itokawa, Qian Shi, Toshiyuki Akiyama, Susan L Morris-Natschke and Kuo-Hsiung Lee* Address: Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA Email: Hideji Itokawa - itokawah@; Qian Shi - qshi1@; Toshiyuki Akiyama - akiyama@; Susan L Morris- Natschke - susan_natschke@; Kuo-Hsiung Lee* - khlee@ * Corresponding author Published: 17 September 2008 Received: 22 May 2008 Accepted: 17 September 2008 Chinese Medicine 2008, 3:11 doi:10.1186/1749-8546-3-11 This article is available from: /content/3/1/11 ? 2008 Itokawa et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract More than 30 Curcuma species (Zingiberaceae) are found in Asia, where the rhizomes of these plants are used as both food and medicine, such as in traditional Chinese medicine. The plants are usually aromatic and carminative, and are used to treat indigestion, hepatitis, jaundice, diabetes, atherosclerosis and bacterial infections. Among the Curcuma species, C. longa, C. aromatica and C. xanthorrhiza are popular. The main constituents of Curcuma species are curcuminoids and bisabolane-type sesquiterpenes. Curcumin is the most important constituent among natural curcuminoids found in these plants. Published research has described the biological effects and chemistry of curcumin. Curcumin derivatives have been evaluated for bioactivity and structure- activity relationships (SAR). In this article, we review the literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant, anti-HIV, chemopreventiv