Recent Alzheimers disease research highlights 英文参考文献.docVIP

Galasko et al. Alzheimer’s Research Therapy 2012,4:14 /content/4/3/14 EDITO RIAL Recent Alzheimer’s disease research highlights Douglas Galasko* , Todd Golde* and Gordon Wilcock* 1 2 3 As co-editors of Alzheimer’s Research a erapy we protein precursor (APP) and increased production of total amyloid β protein (Aβ) with increased relative would like to highlight several of the major translational research advances that have occurred over the past year, produc e second included neuronally during which a tremendous amount of superb science di? erentiated iPS cells from reprogrammed ? broblasts of relevant to the study of Alzheimer’s disease (AD) has two APP gene duplication carriers, two patients with been published. Our selection is, of course, in? uenced by sporadic AD and two controls [2]. In the neuronally our own biases, and selecting particular advances to di? erentiated iPS cell lines from familial and one of the highlight was challenging. Nevertheless, many major two sporadic AD patients, there was higher secretion of scienti? c questions relevant to developing better thera- Aβ40. A further ? nding in these three AD cell lines pies and diagnostics for AD r provided a suggestion of interactions with mechanisms of have chosen to highlight represent evolving areas of tau pathology: higher levels of phospho-tau and active research in AD that raise as many questions as they glycogen synthase kinase e third and most e advances we answer, but o? er some promise that may help us to reach recent paper conducted similar studies using neuronally our shared goal of translating research advances into real adva