Reality check for malaria proteomics 英文参考文献.docVIP

Minireview Reality check for malaria proteomics Robert E Sinden Address: The Malaria Centre, Department of Life Sciences, Imperial College London, SW7 2AZ, UK. Email: r.sinden@imperial.ac.uk Published: 26 February 2009 Genome Biology 2009, 10:211 (doi:10.1186/gb-2009-10-2-211) The electronic version of this article is the complete one and can be found online at /2009/10/2/211 ? 2009 BioMed Central Ltd Abstract New studies highlight the wide diversity of post-translational protein modifications in the intra- erythrocytic stages of the malaria parasite, raising new avenues for inquiry. Now is an exciting time to be in malaria research. The science is moving at an ever faster pace, and the malaria research community has been challenged by Bill and Melinda Gates to re-engage with the ambitious concept of global eradication of malaria. Fundamental to any new efforts to attack the parasite (Plasmodium) or its mosquito vectors (Anopheles species) is the need to understand the regulation and molecular organization of parasite develop- ment throughout its complex life cycle (Figure 1). A new study by Foth et al. [1] published in Genome Biology adds a significant new dimension to this understanding by using methods that detect and delineate a diversity of post- translational modifications to proteins in the asexual stages of the parasite infecting the red blood cells of its human host, the stage that causes the debilitating clinical symptoms of malaria. but might represent a ‘master strategy’ by which quiescent stages of the parasite life cycle are pre-programmed for rapid developmental transitions - for example, when the cell-cycle- arrested gametocytes are transferred from the human blood- stream into the stomach of the mosquito vector. Here, induction of gametogenesis (see Figure 1) by mosquito- derived xanthurenic acid, and a