Reactions of Some New Thienothiophene Derivatives 英文参考文献.docVIP

Molecules 2011, 16, 5142-5148; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Reactions of Some New Thienothiophene Derivatives Yahia Nasser Mabkhot 1,*, Abdullah Mohammad Al-Majid 1, Abdullah Saleh Alamary 1, Ismail Warad 1 and Yamin Sedigi 2 1 Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2 Department of Chemistry, Faculty of Science, Taibah University, P.O. Box 344, Medina, Saudi Arabia * Author to whom correspondence should be addressed; E-Mail: yahia@.sa. Received: 30 May 2011; in revised form: 15 June 2011 / Accepted: 15 June 2011 / Published: 21 June 2011 Abstract: Facile and convenient syntheses of bisdimethylthieno[2,3-b]thiophen-2,5-diyl bis(oxazole-2-amine), bis(1H-imidazol-2-amine), bis((3a)-H-indole),[1,2-a]pyrimidine), bis(1H-imidazo[1,2-b][1,2,4]triazole) and bis(9H-benzo[d]imidazo[1,2-a]imidazole) derivatives incorporating a thieno[2,3-b]thiophene moiety from the versatile and readily accessible 1,1(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)-bis(2-bromo-ethanone) (1) are described. Keywords: bis(2-bromoethanone); bis-thieno[2,3-b]thiophene; bis(oxazole-2-amine); bis-heterocycles; imidazotriazole 1. Introduction We have been interested for some time in the chemical and biological properties of thienothiophene derivatives [1-3]. Thienothiophenes have been developed for different purposes in the pharmaceutical field and have been tested as potential antitumor, antiviral, antibiotic and antiglaucoma drugs or as inhibitors of platelet aggregation [3-8]. In addition, thienothiophenes find potential applications in a wide variety of optical and electronic systems [9-11]. Recently, some conjugated thienothiophenes, structurally related to several current applications have been reported [12-19]. In continuation of these findings, we report herein the synthesis