Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles 英文参考文献.docVIP

下载本文档

2
0
约2.37千字
约 2页
2017-05-13 发布于上海
举报
版权申诉

Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles 英文参考文献

499 Molecules 2000, 5 Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents H. Cerecetto1, R. Di Maio1, G. Seoane1, C. Ochoa2, A. Gómez-Barrio3 and S. Muelas3 1Cátedra de Química Orgánica, Facultad de Química, Universidad de la República General Flores 2124, Montevideo, Uruguay 2Instituto de Química Médica (C.S.I.C.), Madrid, Spain 3Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain Abstract: It describes the synthesis of new 1,2,6-Thiadiazin 1,1-dioxide derivatives using condensation of the Knoevenagel type. The products are evaluated in vitro as trypanocidal agents. Introduction We have previously reported the synthesis of three series of new compounds and the biological evaluation against Trypanosoma cruzi of 1,2,6-Thiadiazin 1,1-dioxide derivatives, structurally related to Nifurtimox [1,2]. The in vitro assay showed that some of them exhibit significant activity against epimastigote forms of T. cruzi, but the cytotoxicity of this type of compounds against Vero cells was highest than the reference drug. Experimental In this work we design new structures, changing the free radical generator. Ar O O N N Change for: O R O R CH3 S N O O O 2 N R = Butyl NO 2 Ar = Hexyl Ciclohexyl Benzyl O O N N O NO 2 NO 2 Phenylethyl Ph S 500 Molecules 2000, 5 All the compounds were prepared according to the following synthetic pathway malonyl chloride ΦCH3 / ? O R O R ? aldehyde p-TsOH H2NSO2NH2 + 2 RNH2 RHNSO2NHR O R O R S O 2 S O 2 Heterocycle with N-óxido function = Results and Discussion All the compounds have been obtained with good yields, and have been characterized by IR, 1H- NMR, 13C-NMR and MS. All the products were tested in vitro against T. cruzi epimastigote forms and that more promising were tested their cytotoxicity. Acknowledgements: The authors thank CYTED (Ciencia y Tecnología para el desarrollo) and RELAQ (Red Latinoamericana de Ciencia Q