Real-Time PCR in HIVTrypanosoma cruzi Coinfection with and without Chagas Disease Reactivation Association with HIV Viral Load and CD4+ Level 英文参考文献.docVIP

Real-Time PCR in HIVTrypanosoma cruzi Coinfection with and without Chagas Disease Reactivation Association with HIV Viral Load and CD4+ Level 英文参考文献.doc

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Real-TimePCRinHIVTrypanosomacruziCoinfectionwithandwithoutChagasDiseaseReactivationAssociationwithHIVViralLoadandCD4Level英文参考文献

Real-TimePCRinHIV/TrypanosomacruziCoinfection withandwithoutChagasDiseaseReactivation: AssociationwithHIVViralLoadandCD4 Level + VeraLu′ciaTeixeiradeFreitas1,SheilaCristinaVicentedaSilva1,2,AnaMarliSartori3,RitaCristina Bezerra4,ElizabethVisoneNunesWestphalen5,TatianeDecarisMolina1,AntonioR.L.Teixeira6 ,Karim YaqubIbrahim3,MariaAparecidaShikanai-Yasuda1,2* 1DepartmentofInfectiousandParasiticDiseases,FaculdadedeMedicina,UniversityofSa?o Paulo(FMUSP),Sa?o Paulo,Brazil,2LaboratoryofImmunology,Hospitaldas Cl?′nicas,FMUSP,Sa?o Paulo,Brazil,3DivisionofClinicsofInfectiousandParasiticDiseases,HospitaldasCl?′nicas,FMUSP,Sa?o Paulo,Brazil,4LaboratoryofParasitology, HospitaldasCl?′nicas,FMUSP,Sa?oPaulo,Brazil,5InstitutoAdolfoLutz,Sa?oPaulo,Brazil,6Laborato′rioMultidisciplinardePesquisaemDoenc?adeChagas,Universidadede Bras?′lia,Bras?′lia,Brazil Abstract Background:ReactivationofchronicChagasdisease,whichoccursinapproximately20%ofpatientscoinfectedwithHIV/ Trypanosoma cruzi (T. cruzi), is commonly characterized by severe meningoencephalitis and myocarditis. The use of quantitativemolecularteststomonitorChagasdiseasereactivationwasanalyzed. Methodology:Polymerasechainreaction(PCR)ofkDNAsequences,competitive(C-)PCRandreal-timequantitative(q)PCR were compared with blood cultures and xenodiagnosis in samples from 91 patients (57 patients with chronic Chagas diseaseand34withHIV/T.cruzicoinfection),ofwhom5hadreactivationofChagasdiseaseand29didnot. Principal Findings: qRT-PCR showed significant differences between groups; the highest parasitemia was observed in patientsinfectedwithHIV/T.cruziwithChagasdiseasereactivation(median1428.90T.cruzi/mL),followedbypatientswith HIV/T.cruziinfectionwithoutreactivation(median1.57T.cruzi/mL)andpatientswithChagasdiseasewithoutHIV(median 0.00T.cruzi/mL).Spearman’scorrelationcoefficientshowedthatxenodiagnosiswascorrelatedwithbloodculture,C-PCR andqRT-PCR.AstrongerSpearmancorrelationindexwasfoundbetweenC-PCRandqRT-PCR,thenumberofpara

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