子宫内膜透明细胞癌的诊治进展.pdfVIP

Diagnosis and treatment of endometrial clear cell carcinoma Abstract Abstract: Endometrium Clear cell carcinoma (ECCC) is a specific pathological type of endometrial Carcinoma, its incidence is approximately 2%~4% of endometrial cancer[3], five-year survival rate is only 52%[4], and its incidence has increased in recent years[1] .ECCC malignancy is high, early vulnerable to distant organs and lymph node metastasis, invasion and metastasis rate significantly higher than the endometrioid adenocarcinoma, uterine cavity lesions could not predict the size of depth of myometrial invasion and there are no transfers outside the Palace[5] .Lack of effective methods of diagnosis and treatment about ECCC, so read through the analysis of literature, both at home and abroad in recent years about diagnosis and treatment of endometrial clear cell carcinoma reviews of new ideas, new methods, and to encourage clinicians to enhance awareness of the ECCC, provide clinicians with new ideas, update of the diagnosis and treatment therapies.Origin of the ECCC as a mullerian duct, a pure clear cell carcinoma less common, often mixed with other types exist, a worse prognosis. Its etiology is unknown, but closely related to P53 mutations.Clinical diagnosis of the ECCC, currently under hysteroscope in endometrial biopsies is considered to be the diagnostic gold standard. Imaging based on Doppler ultrasound, CT and MRI examinations.Molecular biological studies indicate that the HNF1 beta, HE4, CDC25, LICAM, ck7 and cyclingE higher expression in the ECCC, tumor markers in early diagnosis of ECCC is expected to become, but it will t