Rectal Carriage of Extended-Spectrum Beta-Lactamase-Producing Gram-Negative Bacilli in Community Settings in Madagascar 英文参考文献.docVIP

下载本文档

2
0
约2.77万字
约 5页
2017-05-13 发布于上海
举报
版权申诉

Rectal Carriage of Extended-Spectrum Beta-Lactamase-Producing Gram-Negative Bacilli in Community Settings in Madagascar 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Rectal Carriage of Extended-Spectrum Beta-Lactamase-Producing Gram-Negative Bacilli in Community Settings in Madagascar 英文参考文献

RectalCarriageofExtended-SpectrumBeta-Lactamase- ProducingGram-NegativeBacilliinCommunitySettings inMadagascar PerlinotHerindrainy1.,Fre′de′riqueRandrianirina2.,RilaRatovoson2,ElisoaRatsimaHariniana2 ,Yves Buisson1,NathalieGenel3,DominiqueDecre′3,GuillaumeArlet3,AntoineTalarmin2,VincentRichard2* 1InstitutdelaFrancophonie pourlaMe′decine Tropicale,Ventiane,Laos, 2InstitutPasteurdeMadagascar, Antananarivo,Madagascar, 3LaboratoiredeBacte′riologie, Faculte′ deMe′decinePierreetMarieCurie,UPMC,ParisFrance Abstract Background: Extended-spectrum ?-lactamase-producing Enterobacteria (ESBL-PE) emerged at the end of the 1980s, causing nosocomial outbreaks and/or hyperendemic situations in hospitals and long-term care facilities. In recent years, community-acquired infections due to ESBL-PE have spread worldwide, especially across developing countries including Madagascar. Objectives:ThisstudyaimedtodeterminetheprevalenceandriskfactorsofintestinalcarriageofESBL-PEinthecommunity ofAntananarivo. Methods:Non-hospitalizedpatientswererecruitedinthreehealthcentersindifferentsocioeconomicsettings.Freshstool collectedwereimmediatelyplatedonDrigalskiagarcontaining3mg/literofceftriaxone.Gram-negativebacillispecieswere identifiedandESBLproductionwastestedbyadoublediskdiffusion(cefotaximeandceftazidime+/2clavulanate)assay. CharacterizationofESBLswereperfomedbyPCRanddirectsequencing.MolecularepidemiologywasanalysedbyRep-PCR andERIC-PCR. Results: 484 patients were screened (sex ratio =1.03, median age 28 years). 53 ESBL-PE were isolated from 49 patients (carrierrate10.1%).TheisolatesincludedEscherichiacoli(31),Klebsiellapneumoniae(14),Enterobactercloacae(3),Citrobacter freundii (3), Kluyvera spp. (1) and Pantoae sp.(1). In multivariate analysis, only the socioeconomic status of the head of householdwasindependentlyassociatedwithESBL-PEcarriage,povertybeingthepredominantriskfactor. Conclusions: The prevalence of carriage of ESBL in the community of Antananarivo is one of the highest re