Recombination between Poliovirus and Coxsackie A Viruses of Species C A Model of Viral Genetic Plasticity and Emergence 英文参考文献.docVIP

Viruses 2011, 3, 1460-1484; doi:10.3390/v3081460 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence Nicolas Combelas 1,2, Barbara Holmblat 1,2, Marie-Line Joffret 1,2, Florence Colbère-Garapin 1,2 and Francis Delpeyroux 1,2, * 1 Biologie des Virus Entériques, Institut Pasteur, 75724 Paris-cedex 15, France; E-Mails: belas@pasteur.fr (N.C.); barbara.holmblat@pasteur.fr (B.H.); marie-line.joffret@pasteur.fr (M.-L.J.); florence.colbere-garapin@pasteur.fr (F.C.-G.) INSERM U994, Institut National de Santé et de La Recherche Médicale, 75724 Paris-cedex 15, France 2 * Author to whom correspondence should be addressed; E-Mail: francis.delpeyroux@pasteur.fr. Received: 2 June 2011; in revised form: 3 August 2011 / Accepted: 3 August 2011 / Published: 17 August 2011 Abstract: Genetic recombination in RNA viruses was discovered many years ago for poliovirus (PV), an enterovirus of the Picornaviridae family, and studied using PV or other picornaviruses as models. Recently, recombination was shown to be a general phenomenon between different types of enteroviruses of the same species. In particular, the interest for this mechanism of genetic plasticity was renewed with the emergence of pathogenic recombinant circulating vaccine-derived polioviruses (cVDPVs), which were implicated in poliomyelitis outbreaks in several regions of the world with insufficient vaccination coverage. Most of these cVDPVs had mosaic genomes constituted of mutated poliovaccine capsid sequences and part or all of the non-structural sequences from other human enteroviruses of species C (HEV-C), in particular coxsackie A viruses. A study in Madagascar showed that recombinant cVDPVs had been co-circulating in a small population of children with many different HEV-C types. This viral