Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus 英文参考文献.docVIP

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Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus 英文参考文献.doc

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Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus 英文参考文献

RefiningtheGlobalSpatialLimitsofDengueVirus TransmissionbyEvidence-BasedConsensus OliverJ.Brady1,2*,PeterW.Gething1,SamirBhatt1,JaneP.Messina1,JohnS.Brownstein3, AnneG.Hoen4,CatherineL.Moyes1,AndrewW.Farlow1,ThomasW.Scott5,6,SimonI.Hay1,6 * 1Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom, 2Oxitec Ltd., Abingdon, United Kingdom, 3Department of Pediatrics, Harvard Medical School and Children’s Hospital Informatics Program, Boston Children’s Hospital, Boston, Massachusetts, United States of America, 4Department of Community and Family Medicine, Dartmouth College, Hanover, New Hampshire, United States of America, 5Department of Entomology, UniversityofCaliforniaDavis,Davis,California,UnitedStatesofAmerica,6FogartyInternationalCenter,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesof America Abstract Background: Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distributionremainshighlyuncertain.Challengesindiagnosisanddiagnosticmethodsaswellashighlyvariablenational healthsystemsmeannosingledatasourcecanreliablyestimatethedistributionofthisdisease.Assuch,thereisalackof agreement on national dengue status among international health organisations. Here we bring together all available informationondengueoccurrenceusinganovelapproachtoproduceanevidenceconsensusmapofthediseaserange thathighlightsnationswithanuncertaindenguestatus. Methods/PrincipalFindings:Abaselinemethodologywasusedtoassessarangeofevidenceforeachcountry.Inregions wheredenguestatuswasuncertain,additionalevidencetypeswereincludedtoeitherclarifydenguestatusorconfirmthat itisunknownatthistime.Analgorithmwasdevelopedthatassessesevidencequalityandconsistency,givingeachcountry anevidenceconsensusscore.Usingthisapproach,wewereabletogenerateacontemporaryglobalmapofnational-level denguestatusthatassignsarelativemeasureofcertaintyandidentifiesgapsintheavailableevidence. Conclusion: The map prod