Rescue of a H3N2 Influenza Virus Containing a Deficient Neuraminidase Protein by a Hemagglutinin with a Low Receptor-Binding Affinity 英文参考文献.docVIP

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Rescue of a H3N2 Influenza Virus Containing a Deficient Neuraminidase Protein by a Hemagglutinin with a Low Receptor-Binding Affinity 英文参考文献.doc

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Rescue of a H3N2 Influenza Virus Containing a Deficient Neuraminidase Protein by a Hemagglutinin with a Low Receptor-Binding Affinity 英文参考文献

RescueofaH3N2InfluenzaVirusContainingaDeficient NeuraminidaseProteinbyaHemagglutininwithaLow Receptor-BindingAffinity MathildeRichard1*,AlexandraErny1,BertrandCare′2,Aure′lienTraversier1,MendyBarthe′le′my1, AlanHay2,YiPuLin2,OlivierFerraris1,BrunoLina1 1LaboratoireVirologieetPathologieHumaine(VirPath),EMR4610–UCBL,Faculte′ deMe′decineRTHLaennec,Universite′ deLyon,Lyoncedex,France,2Universite′ de Lyon,CNRS,INRIA,INSA-Lyon,LIRIS,UMR5205,F-69621,Lyon,France,3TheNationalInstituteforMedicalResearch,MillHill,London,UnitedKingdom Abstract Influenza viruses possess at their surface two glycoproteins, the hemagglutinin and the neuraminidase, of which the antagonisticfunctionshavetobewellbalancedforthevirustogrowefficiently.Ferrarisetal.isolatedin2003–2004viruses lackingbothaNAgeneandprotein(H3NA-viruses)(FerrarisO.,2006,Vaccine,24(44–46):6656-9).Inthisstudyweshowed thatthehemagglutininsoftwooftheH3NA-viruseshavereducedaffinityforSAa2.6Galreceptors,between49and128 times lower than that of the A/Moscow/10/99 (H3N2) virus and no detectable affinity for SAa2.3Gal receptors. We also showedthatthelowhemagglutininaffinityoftheH3NA-virusescompensatesforthelackofNAactivityandallowsthe restoration of the growth of an A/Moscow/10/99 virus deficient in neuraminidase. These observations increase our understanding of H3NA- viruses in relation to the balance between the functional activities of the neuraminidase and hemagglutinin. Citation:RichardM,ErnyA,Care′B,TraversierA,Barthe′le′myM,etal.(2012)RescueofaH3N2InfluenzaVirusContainingaDeficientNeuraminidaseProteinbya HemagglutininwithaLowReceptor-BindingAffinity.PLoSONE7(5):e33880.doi:10.1371/journal.pone.0033880 Editor:RobertJ.Geraghty,UniversityofMinnesota,UnitedStates ReceivedMay20,2011;AcceptedFebruary21,2012;PublishedMay1,2012 Copyright: ? 2012 Richard et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninan