Repertoire Enhancement with Adoptively Transferred Female Lymphocytes Controls the Growth of Pre-Implanted Murine Prostate Cancer 英文参考文献.docVIP

下载本文档

2
0
约3.97万字
约 8页
2017-05-13 发布于上海
举报
版权申诉

Repertoire Enhancement with Adoptively Transferred Female Lymphocytes Controls the Growth of Pre-Implanted Murine Prostate Cancer 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Repertoire Enhancement with Adoptively Transferred Female Lymphocytes Controls the Growth of Pre-Implanted Murine Prostate Cancer 英文参考文献

RepertoireEnhancementwithAdoptivelyTransferred FemaleLymphocytesControlstheGrowthofPre- ImplantedMurineProstateCancer RobertR.Jenq1,2.,MichaelA.Curran3.,GabrielleL.Goldberg1,ChenLiu4,JamesP.Allison3, MarcelR.M.vandenBrink1* 1DepartmentofImmunologyandMedicine,MemorialSloan-KetteringCancerCenter,NewYork,NewYork,UnitedStatesofAmerica,2WeillCornellMedicalCollege,New York,NewYork,UnitedStatesofAmerica,3HowardHughesMedicalInstitute,DepartmentofImmunology,MemorialSloan-KetteringCancerCenter,NewYork,NewYork, UnitedStatesofAmerica,4DepartmentofPathology,ImmunologyandLaboratoryMedicine,UniversityofFlorida,CollegeofMedicine,Gainesville,Florida,UnitedStates ofAmerica Abstract Background:Inprostatecancer,genesencodingandrogen-regulated,Y-chromosome-encoded,andtissue-specificantigens may all be overexpressed. In the adult male host, however, most high affinity T cells targeting these potential tumor rejectionantigenswillberemovedduringnegativeselection.Incontrast,thefemalematureT-cellrepertoireshouldcontain abundantprecursorscapableofrecognizingtheseclassesofprostatecancerantigensandmediatingeffectiveanti-tumor immuneresponses. Methodology/Principal Findings: We find that syngeneic TRAMP-C2 prostatic adenocarcinoma cells are spontaneously rejected in female hosts. Adoptive transfer of na?¨ve female lymphocytes to irradiated male hosts bearing pre-implanted TRAMP-C2 tumorcells slows tumorgrowth andmediates tumorrejection in some animals. The success ofthis adoptive transfer was dependent on the transfer of female CD4 T cells and independent of the presence of CD25-expressing regulatoryTcellsinthetransferredlymphocytes.WeidentifyinfemaleCD4TcellsstimulatedwithTRAMP-C2adominant MHCII-restrictedresponsetotheY-chromosomeantigenDBY.Furthermore,CD8Tcellresponsesinfemalelymphocytesto theimmunodominantMHCI-restrictedantigenSPAS-1aremarkedlyincreasedcomparedtomalemice.Finally,wefindno exacerbationofgraft-versus-hostdiseaseineithersyngeneicorminor-antigenmismatchedallogeneiclymphocyteadop