Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi 英文参考文献.docVIP

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Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi 英文参考文献.doc

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Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi 英文参考文献

Open Access Re rch 2007ObadoetVoal.lumesea8, Issue 3, Article R37 Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi Samson O Obado*, Christopher Bot*, Daniel Nilsson?, Bjorn Andersson? and John M Kelly* Addresses: *Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. ?Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vag, S-171 77 Stockholm, Sweden. Correspondence: John M Kelly. Email: john.kelly@lshtm.ac.uk Published: 12 March 2007 Received: 3 November 2006 Revised: 16 January 2007 Accepted: 12 March 2007 Genome Biology 2007, 8:R37 (doi:10.1186/gb-2007-8-3-r37) The electronic version of this article is the complete one and can be found online at /2007/8/3/R37 ? 2007 Obado et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. RepetitiveclpustCeersnttrhoaDNAmt ceorensandtainincentromeresdietgeTnreyrpaatneorseinotmrtrypanosomesoaelcruziemen/itandts, and initTrypanosomathe case of itT. bbruceirucei/itcan/it, repebetitilocalisedve DNA.to/pregions between directional gene Abstract Background: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has not been identified. Results: We report evidence on the location and nature of centromeric DNA in Trypanosoma cruzi and Trypanosoma brucei. In T. cruzi, we used telomere-associated chromosome fragmentation and found that GC-rich transcriptional strand-switch domains composed predominantly of degenerate retrotranposons are a