Role of Single Nucleotide Polymorphisms of KIF1B Gene in HBV-Associated Viral Hepatitis 英文参考文献.docVIP

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Role of Single Nucleotide Polymorphisms of KIF1B Gene in HBV-Associated Viral Hepatitis 英文参考文献.doc

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Role of Single Nucleotide Polymorphisms of KIF1B Gene in HBV-Associated Viral Hepatitis 英文参考文献

RoleofSingleNucleotidePolymorphismsofKIF1BGene inHBV-AssociatedViralHepatitis AhmedAl-Qahtani1,2*,MashaelAl-Anazi1,NishaA.Viswan1,NisreenKhalaf1,AymanA.Abdo2,3, FaisalM.Sanai2,4,HamadAl-Ashgar5,MohammedAl-Ahdal1,6 1DepartmentofInfectionandImmunity,ResearchCenter,KingFaisalSpecialistHospitalResearchCenter,Riyadh,SaudiArabia,2LiverDiseaseResearchCenter,King SaudUniversity,Riyadh,SaudiArabia,3DepartmentofMedicine,CollegeofMedicine,KingSaudUniversity,Riyadh,SaudiArabia,4DepartmentofHepatobiliaryScience andLiverTransplantation,KingAbdulazizMedicalCity,Riyadh,SaudiArabia,5DepartmentofMedicine,KingFaisalSpecialistHospitalResearchCenter,Riyadh,Saudi Arabia,6DepartmentofPathologyandLaboratoryMedicine,KingFaisalSpecialistHospitalResearchCenter,Riyadh,SaudiArabia Abstract Background/Aim: Kinesin family member 1B (KIF1B) gene resides in the chromosomal region 1p36.22 and has been reportedtohavefrequentdeletionsinavarietyofhumancancers.Arecentgenomewideassociationstudy(GWAS)study conducted on a Chinese population has reported the involvement of a KIF1B genetic variant in Hepatitis B virus (HBV)- relatedhepatocellularcarcinoma(HCC).ThisstudyaimstoinvestigatethesignificanceofKIF1BgeneticvariationsinHBV- associatedhepatitisinpatientsofSaudiArabianethnicity. Methods:TaqMangenotypingassaywasusedtoinvestigatetheassociationofthreeSNPs(rrand rs3748578) in 584 normal healthy controls and 660 HBV-infected patients. The patients were categorized into inactive carriers(CaseI),activecarriers(CaseII),Cirrhosis(CaseIII)andCirrhosis-HCC(CaseIV)sub-groups. Results:SinceSNPsrndrs3748578areinstronglinkagedisequilibrium(LD)withronlyresultsforthe latterSNParereported.Therefore,theallelefrequencyofrmongHBV-infectedpatientsandhealthycontrols were comparable and therefore, no significant association was observed (P=0.2811, Odds Ratio (OR) 0.897). A similar analysiswasperformedamongthedifferentsub-groupsinordertodeterminewhetherKIF1BSNPswereassociatedw