Role of regulatory and proinflammatory T-cell populations in allergic diseases 英文参考文献.docVIP

下载本文档

3
0
约2.13万字
约 6页
2017-05-13 发布于上海
举报
版权申诉

Role of regulatory and proinflammatory T-cell populations in allergic diseases 英文参考文献.doc

1、本文档共6页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Role of regulatory and proinflammatory T-cell populations in allergic diseases 英文参考文献

REVIEWARTICLE RoleofRegulatoryandProinflammatoryT-CellPopulations inAllergicDiseases KanamiOrihara,PhD,*SusumuNakae,PhD,*TRubyPawankar,MD,PhD,t andHirohisaSaito,MD,PhD*T anBunhygienic^environmentsurroundedbymanymicrobial Abstract: Regulatory T (Treg) cells are considered to inhibit the componentsislimitedtoearlychildhood.1 Accordingtothe development of both type 1 (Th1) and type 2 helper T (Th2) cells. However,itisrecentlyreportedthattherearereducednumbersofTreg classic Th1/Th2 paradigm theory, this could be typically speculated as shown in Figure 1. ATh2-dominant immune cellsinpatientswithallergicdiseasesascomparedwithindividuals systemdevelopsinanindividualwhentheimmunesystemis who have high levels of serum immunoglobulin E and blood exposed to allergens without prior exposure to microbial eosinophilsbutareasymptomatic.Therefore,Tregcellsmaysuppress componentssuchasendotoxinearlyinlife.Ontheotherhand, theonsetofallergicdiseasebydown-regulatingothertypesofimmune the development of allergen (antigen)-speci?c Th1 cells is cells besides Th1 and Th2 cells. The newly discovered interleukin triggered by simultaneous exposure to the antigen and 17Yproducing helper T cells that are responsible for autoimmune microbial components. After childhood, the proportion of in?ammatorydiseasesmaycounteractTregcellseveninallergicdiseases. Th1/Th2cellsisnotdrasticallyalteredbymicrobialexposure TheTh2cellsthatarecapableofproducingofhighlevelsoftumornecrosis becauseofadecreaseinthenumberofnaivehelperTcellsthat factor-mayalsobeinvolvedinin?ammationinallergicdiseases.Inthis canreactwithcommonallergens. review,wefurtherdiscusstheroleofTh1,Th2,interleukin17Yproducing TheincidenceofTh1-mediatedautoimmunediseasesis helperTcells,andTregcellsinallergicdiseasesbyusingthebalancing knowntohaveincreasedinthelasthalfcenturyinparallelwith squaremodelandthefactorsdifferentiatingbetweenpatientswithclinical manifestations of allergic symptomatic and atopic individuals who are sensitizedbutasymptoma