Science review Quantitative acid–base physiology using the Stewart model 英文参考文献.docVIP

Critical Care December 2004 Vol 8 No 6 Wooten Review Science review: Quantitative acid–base physiology using the Stewart model E Wrenn Wooten Attending Physician, Radiology Associates, PA, Little Rock, Arkansas, USA Corresponding author: E Wrenn Wooten, wootenew@ Published online: 2 July 2004 Critical Care 2004, 8:448-452 (DOI 10.1186/cc2910) This article is online at /content/8/6/448 ? 2004 BioMed Central Ltd Abstract There has been renewed interest in quantifying acid–base disorders in the intensive care unit. One of the methods that has become increasingly used to calculate acid–base balance is the Stewart model. This model is briefly discussed in terms of its origin, its relationship to other methods such as the base excess approach, and the information it provides for the assessment and treatment of acid–base disorders in critically ill patients. Keywords acid–base, base excess, Stewart model Introduction of the various species under a given set of conditions [5,8–12]. This function is calculated at the normal values and then the abnormal values; from these the degree of change is obtained to give information about the clinical acid–base status of the patient. All of the apparently ‘different’ methods for assessing acid–base balance arise from this common framework [5,12]. Acid–base derangements are commonly encountered in the critical care unit [1], and there is renewed interest in the precise description of these disorders in critically ill patients [2–5]. This new interest has led to a renovation of the quantitative assessment of physiological acid–base balance, with increasing use of the Stewart model (strong ion difference [SID] theory) to calculate acid–base balance in the critically ill [2,3,6,7]. This method is discussed, particularly as In the Stewart method, charge is taken as the property of interest [7,11,13]. Using