Self-organizing Mechanism for Development of Space-filling Neuronal Dendrites 英文参考文献.docVIP

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Self-organizing Mechanism for Development of Space-filling Neuronal Dendrites 英文参考文献.doc

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Self-organizing Mechanism for Development of Space-filling Neuronal Dendrites 英文参考文献

Self-organizingMechanismforDevelopment ofSpace-fillingNeuronalDendrites Kaoru Sugimura1¤*,Kohei Shimono2,Tadashi Uemura1,Atsushi Mochizuki3* 1GraduateSchoolofBiostudies,KyotoUniversity,Kyoto,Japan,2DepartmentofScience,KyotoUniversity,Kyoto,Japan,3DivisionofTheoreticalBiology,NationalInstitute forBasicBiology,Okazaki,Japan Neuronsdevelopdistinctivedendriticmorphologiestoreceiveandprocessinformation.Previousexperimentsshowed thatcompetitivedendro-dendriticinteractionsplaycriticalrolesinshapingdendritesofthespace-fillingtype,which uniformlycovertheirreceptivefield.Weincorporatedthisfindinginconstructinganewmathematicalmodel,inwhich reactiondynamicsoftwochemicals(activatorandsuppressor)arecoupledtoneuronaldendritegrowth.Ournumerical analysis determined the conditions for dendritic branching and suggested that the self-organizing property of the proposedsystemcanunderliedendritogenesis.Furthermore,wefoundaclearcorrelationbetweendendriteshapeand the distribution of the activator, thus providing a morphological criterion to predict the in vivo distribution of the hypotheticalmolecularcomplexesresponsiblefordendriteelongationandbranching. Citation:SugimuraK,ShimonoK,UemuraT,MochizukiA(2007)Self-organizingmechanismfordevelopmentofspace-fillingneuronaldendrites.PLoSComputBiol3(11): e212.doi:10.1371/journal.pcbi.0030212 branches (Figure 1C) [11,14]. It should be noted that the qualitativelysameinhibitorydendro-dendriticinteractionis Introduction One of the primary interests in developmental biology is theemergenceoffunctionthroughmorphogenesis.Morpho- logical diversity of dendrites and its impact on neuronal computation perfectly represents the importance of this problem: shapes of dendrites are highly variable from one neuronaltypetoanother,andithasbeensuggestedthatthis diversity supports differential processing of information in eachtypeofneuron[1–3].Therefore,patterningofneuronal class-speci?c dendrites is a process to produce shapes that realizes the physiological func