Sequence and structural analysis of BTB domain proteins 英文参考文献.docVIP

Open Access Re rch 2005StogiosetVoal.lumesea6, Issue 10, Article R82 Sequence and structural analysis of BTB domain proteins Peter J Stogios*, Gregory S Downs?, Jimmy JS Jauhal*, Sukhjeen K Nandra* and Gilbert G Privé*?§ Addresses: *Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada. ?Bioinformatics Certificate Program, Seneca College, Toronto, Ontario, M3J 3M6, Canada. ?Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. §Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada. Correspondence: Gilbert G Privé. E-mail: prive@uhnres.utoronto.ca Published: 15 September 2005 Received: 29 March 2005 Revised: 20 June 2005 Accepted: 3 August 2005 Genome Biology 2005, 6:R82 (doi:10.1186/gb-2005-6-10-r82) The electronic version of this article is the complete one and can be found online at /2005/6/10/R82 ? 2005 Stogios et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. eBTBteupiknasAr.domainyno/aptnesalryesproteinsviseaoflsthea hiproteingh strucarchitecture,tural conservgenomication anddistributionadapta andto isequencefferent moconservationdes of self-asofsoBTBciatiodomainn and inproteinsteractionins w17itfullyh nonsequenced-BTB pro- Abstract Background: The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. Results: We surveyed the protein architectur