Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus 英文参考文献.docVIP

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Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus 英文参考文献.doc

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Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus 英文参考文献

Sequence-BasedPredictionforVaccineStrainSelection andIdentificationofAntigenicVariabilityinFoot-and- MouthDiseaseVirus RichardReeve1,2*,BelindaBlignaut3,4,JanJ.Esterhuysen3,PamelaOpperman3,4,LouiseMatthews1,2 , ElizabethE.Fry5,TjaartA.P.deBeer6¤a,JacquesTheron4,ElizabethRieder7,WilnaVosloo3¤b,HesterG. O’Neill8,DanielT.Haydon1,2,FrancoisF.Maree3 1BoydOrrCentreforPopulationandEcosystemHealth,UniversityofGlasgow,Glasgow,United Kingdom, 2InstituteofBiodiversity,Animal HealthandComparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 3Transboundary Animal Diseases Programme, OnderstepoortVeterinaryInstitute,AgriculturalResearchCouncil,Onderstepoort,SouthAfrica,4DepartmentofMicrobiologyandPlantPathology,UniversityofPretoria, Pretoria, South Africa, 5Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, United Kingdom, 6Bioinformatics and ComputationalBiologyUnit,UniversityofPretoria,Pretoria,SouthAfrica,7ForeignAnimalDiseaseResearchUnit,UnitedStatesDepartmentofAgriculture,Agricultural Research Service, Plum Island Animal Disease Center, Greenport, New York, United States of America, 8Biochemistry Division, North-West University, Potchefstroom, SouthAfrica Abstract Identifying when past exposure to an infectious disease will protect against newly emerging strains is central to understandingthespreadandtheseverityofepidemics,butthepredictionofviralcross-protectionremainsanimportant unsolvedproblem.Forfoot-and-mouthdiseasevirus(FMDV)researchinparticular,improvedmethodsforpredictingthis cross-protectionarecriticalforpredictingtheseverityofoutbreakswithinendemicsettingswheremultipleserotypesand subtypes commonly co-circulate, aswell as fordeciding whether appropriate vaccine(s)exist andhow muchtheycould mitigatetheeffectsofanyoutbreak.Toidentifyantigenicrelationshipsandtheirpredictors,weusedlinearmixedeffects models to account for variation in pairwise cross-neutral