Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study 英文参考文献.docVIP

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Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study 英文参考文献.doc

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Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study 英文参考文献

SerumAcylatedGhrelinIsNegativelyCorrelatedwiththe InsulinResistanceIntheCODINGstudy PeyvandAmini1,DannyWadden1,FarrellCahill1,EdwardRandell2,SudeshVasdev1,XihuaChen3, WayneGulliver1,WeizhenZhang4,HongweiZhang1,YanqingYi1,GuangSun1* 1DivisionofMedicine,MemorialUniversityofNewfoundland,St.John’s,NewfoundlandandLabrador,Canada,2DisciplineofLaboratoryMedicine,MemorialUniversityof Newfoundland,St.John’s,NewfoundlandandLabrador,Canada,3DivisionofBioMedicalSciences,MemorialUniversityofNewfoundland,St.John’s,Newfoundlandand Labrador,Canada,4DepartmentofPhysiologyandPathophysiology,SchoolofBasicMedicalSciences,PekingUniversity,Beijing,People’sRepublicofChina Abstract Objective:Ghrelinisa28-aminoacidorexigenicpeptidesynthesizedmainlyinthestomach.Acuteadministrationofghrelin hasbeenfoundtodecreaseinsulinsecretion.However,littledataisavailableregardingwhetherghrelincontributestothe long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the association betweencirculatingghrelinandinsulinresistanceinalargepopulationbasedstudy. Design: A total of 2082 CODING study (Complex Diseases in the Newfoundland population: Environment and Genetics) subjectswereassessed.SubjectswereofatleastthirdgenerationNewfoundlanddescent,betweentheagesof20and79 years, and had no serious metabolic, cardiovascular, or endocrine diseases. Ghrelin was measured with an Enzyme Immunoassay method. Insulin and fasting glucose were measured by Immulite 2500 autoanalyzer and Lx20 clinical chemistryanalyzer,respectively.HomeostaticModelAssessmentofbcellfunction(HOMA-b)andInsulinResistance(HOMA- IR)andQuantitativeInsulin-sensitivityCheckIndex(QUICKI)wereusedformeasurementofinsulinresistance. Results:Partialcorrelationanalysesshowedasignificantnegativecorrelationbetweencirculatingghrelinandinsulinlevel and insulin resistance in the entire cohort and also in men and women separately. The aforementioned correlation was independentofage,percentageoftrunkfatandHDL-ch