Short-Term Environmental Enrichment Enhances Adult Neurogenesis, Vascular Network and Dendritic Complexity in the Hippocampus of Type 1 Diabetic Mice 英文参考文献.docVIP

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Short-Term Environmental Enrichment Enhances Adult Neurogenesis, Vascular Network and Dendritic Complexity in the Hippocampus of Type 1 Diabetic Mice 英文参考文献.doc

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Short-Term Environmental Enrichment Enhances Adult Neurogenesis, Vascular Network and Dendritic Complexity in the Hippocampus of Type 1 Diabetic Mice 英文参考文献

Short-TermEnvironmentalEnrichmentEnhancesAdult Neurogenesis,VascularNetworkandDendritic ComplexityintheHippocampusofType1DiabeticMice JuanBeauquis1,PaulinaRoig1,AlejandroF.DeNicola1,2,FlaviaSaravia1,2 * 1Institute of Biology and Experimental Medicine, National Research Council (CONICET), Buenos Aires, Argentina, 2Department of Biochemistry, Faculty of Medicine, UniversityofBuenosAires,BuenosAires,Argentina Abstract Background:Severalbraindisturbanceshavebeendescribedinassociationtotype1diabetesinhumans.Inanimalmodels, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memoryinconditionslikestress,agingandneurodegenerativeprocesses. Methodology/PrincipalFindings:Weexploredthemodulationofhippocampalalterationsinstreptozotocin-inducedtype 1diabeticmicebyenvironmentalenrichment.Indiabeticmicehousedinstandardconditionswefoundareductionofadult neurogenesisinthedentategyrus,decreaseddendriticcomplexityinCA1neuronsandasmallervascularfractionalareain thedentategyrus,comparedwithcontrolanimalsinthesamehousingcondition.Ashortexposure-10days-toanenriched environmentwasabletoenhanceproliferation,survivalanddendriticarborizationofnewbornneurons,torecoverdendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabeticanimals. Conclusions/Significance:Theenvironmentalcomplexityseemstoconstituteastrongstimulatorcompetenttorescuethe diabeticbrainfromneurodegenerativeprogression. Citation:BeauquisJ,RoigP,DeNicolaAF,SaraviaF(2010)Short-TermEnvironmentalEnrichmentEnhancesAdultNeurogenesis,VascularNetworkandDendritic ComplexityintheHippocampusofType1DiabeticMice.PLoSONE5(11):e13993.doi:10.1371/journal.pone.0013993 Editor:MartinGiurfa,CentredeRecherchessurlaCognitionAnimale-CentreNationaldelaRechercheScientifiqueandUniversite′ PaulS